Status:
ACTIVE_NOT_RECRUITING
Muscle Insulin Resistance in Aging (Mirage)
Lead Sponsor:
AdventHealth Translational Research Institute
Conditions:
Insulin Resistance
Sarcopenia
Eligibility:
All Genders
65-80 years
Phase:
NA
Brief Summary
The purpose of this study is to provide information regarding potential factors underlying metabolic dysfunction, insulin resistance, and loss of muscle mass in aging muscle.
Detailed Description
Study Objectives: 1. To determine the effects of diet-induced weight loss with and without the addition of exercise on mitochondrial biogenesis and energetic capacity, cellular redox state and insuli...
Eligibility Criteria
Inclusion
- 65-80 years of age
- Stable weight (No Gain/Loss of \>10 lbs in 6 months)
- Sedentary (≤ 1 continuous exercise/week)
- Non-smoker
- BMI ≥ 30 kg/m2
- Resting Blood Pressure ≤ 150 millimeters of mercury systolic and ≤ 95 millimeters of mercury diastolic
- Note from Primary care physician/Cardiologist for exercise clearance if positive stress test symptoms were observed from exercise test
- Must be willing to washout for 14 days from all diabetes medication and independent in self blood glucose monitoring during the washout periods (those with diabetes only)
Exclusion
- Clinically significant cardiovascular disease including history of myocardial infarction, within the past year
- Peripheral Vascular Disease
- Hepatic, renal, muscular/neuromuscular, or active hematologic/oncologic disease
- Clinically diminished pulse
- Presence of bruits in lower extremities
- Previous history of pulmonary emboli
- Peripheral Neuropathy
Key Trial Info
Start Date :
June 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT02230839
Start Date
June 1 2014
End Date
December 1 2025
Last Update
August 3 2025
Active Locations (1)
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1
Translational Research Institute for Metabolism and Diabetes
Orlando, Florida, United States, 32804