Status:
COMPLETED
Exercise, Brain Imaging, Cognition, and Gait in Parkinsonism
Lead Sponsor:
Oregon Health and Science University
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Parkinson's Disease
Eligibility:
All Genders
50-90 years
Phase:
NA
Brief Summary
There is emerging research detailing the relationship between balance/gait/falls and cognition. Imaging studies also suggest a link between structural and functional changes in the frontal lobe (a reg...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Aged 50-90 years old. No musculoskeletal or peripheral or central nervous system disorders (other than idiopathic Parkinson disease (iPD) or parkinsonism) that could significantly affect balance or gait .
- Capable of following directions. iPD subjects: UK Brain Bank criteria, i.e., bradykinesia and at least one of the following: rest tremor, muscular rigidity, and postural instability not cause by visual, vestibular, cerebellar or proprioceptive dysfunction. Unilateral onset, response to levodopa.
- Parkinsonism subjects: Gait characterized by slow short steps, shuffling gait and may be wide-based, with FoG, postural instability.
- Exclusion criteria:
- Inability to stand or walk for 2 min without an assistive device Recent changes in medication Excessive use of alcohol or recreational drugs, Contraindications to MRI scans (eg, claustrophobia, metal in body) Intervention subjects will be excluded if: 1) participating in a vigorous exercise program more than 2 x/week, 2) A medical condition that contraindicates exercise participation.
- Parkinsonism subjects: iPD and Parkinson plus syndromes such as Progressive Supranuclear Palsy, Multiple System Atrophy, Corticobasal Syndrome, or Cerebellar Ataxia.
- Idiopathic PD subjects: Same as above and deep brain stimulation electrodes. Significant tremor that would interfere withMRI scan.
- Control subjects: Will be matched for age and gender to iPD and parkinsonism groups.
- \-
Exclusion
Key Trial Info
Start Date :
August 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2018
Estimated Enrollment :
94 Patients enrolled
Trial Details
Trial ID
NCT02231073
Start Date
August 1 2014
End Date
October 1 2018
Last Update
July 25 2019
Active Locations (1)
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1
Oregon Health & Science University
Portland, Oregon, United States, 97239