Status:
COMPLETED
Vascular Effects of Achieving Minimal Disease Activity in Psoriatic Arthritis - a 2 Year Prospective Cohort Study
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Psoriatic Arthritis
Atherosclerosis
Eligibility:
All Genders
Phase:
NA
Brief Summary
Objectives To investigate the effect of achieving minimal disease activity (MDA) using a protocolized treatment strategy on the progression of subclinical atherosclerosis and arterial stiffness in pso...
Detailed Description
Background: Patients with psoriatic arthritis (PsA) experience substantial morbidity and unfavorable outcomes at referral centers. Although studies on all-cause mortality have yielded mixed results, ...
Eligibility Criteria
Inclusion
- PsA attending the outpatient clinic of the Prince of Wales Hospital (PWH) who fulfilled the Classification of Psoriatic Arthritis criteria
Exclusion
- 1\) have a history of overt CVD (myocardial infarction, percutaneous transluminal coronary angioplasty, surgery for ischemic heart disease, stroke, transient ischemic attack, carotid endarterectomy, peripheral arterial reconstructive surgery, or limb amputation), or 2) are on aspirin, or HMG-CoA reductase inhibitors (statins) or angiotensin-converting-enzyme inhibitor (ACEI), or 3) have significant co-morbidities including severe renal impairment defined as a glomerular filtration rate of less than 30 mL/min/1.73m2, alanine aminotransferase (ALT) ≥2xULN, hemoglobin level \<8.5gm/dl, white blood cell count \<3.5x109/liter, platelet count\<100x109/liter, or 4) female of childbearing potential who are unwilling to use adequate contraception, pregnant or breastfeeding women, or 5) they are on glucocorticoids at a dose \>10mg/day (equivalent dose of prednisolone)
Key Trial Info
Start Date :
March 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2018
Estimated Enrollment :
113 Patients enrolled
Trial Details
Trial ID
NCT02232321
Start Date
March 1 2014
End Date
May 1 2018
Last Update
July 19 2018
Active Locations (1)
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1
Prince of Wales Hospital
Hong Kong, China