Status:
UNKNOWN
Ketamine and Glutamate After Brain Injury : a Microdialysis Study
Lead Sponsor:
Pierre-Julien CUNGI
Conditions:
Head Trauma
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The objective of the study is to compare the effects of 48 hours ketamine infusion versus sufentanil infusion on brain glutamate concentrations measured with microdialysis after traumatic brain injury...
Detailed Description
Inclusion of 20 consecutive head trauma patients. Randomization and double-blind to compare the effects of ketamine versus sufentanil on brain glutamate concentrations measured with microdialysis. Ke...
Eligibility Criteria
Inclusion
- \> 18 years old
- Glasgow Coma Scale (GCS) \< 9
- \> 3 days of sedation expected at the arrival
Exclusion
- pregnancy
- \< 18 years old
- estimated survival \< 48 hours post-trauma
- expected sedation \< 3 days
- coagulation impairment (platelets\<100.000/mm3 and prothrombin time (TP) \<60%)
- Cardiac arrest before ICU admission
- Admission \> 12 hours after trauma
- Multimodal monitoring implanted \> 24 hours post trauma
- Participation to the study refused by the next of kind
- No next of kind
Key Trial Info
Start Date :
October 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2017
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT02232347
Start Date
October 1 2014
End Date
May 1 2017
Last Update
September 5 2014
Active Locations (1)
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1
Sainte Anne Military Teaching Hospital
Toulon, France, 83130