Status:
COMPLETED
Impact of Breathing Maneuvers on the Oxygenation Supply of the Heart Assessed With MRI in Patients With Coronary Artery Disease
Lead Sponsor:
Insel Gruppe AG, University Hospital Bern
Conditions:
Coronary Artery Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Patients with an impaired blood supply of the heart routinely receive oxygen in order to improve or preserve the oxygen supply of the heart muscle in acute cardiac care. In recent studies a new innova...
Detailed Description
Background Patients with acute myocardial ischemia receive oxygen as a standard measure of care to maintain or improve the myocardial oxygen supply. In 1975 Neil et al. were able to show that higher ...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Patients with known relevant coronary artery stenosis (defined by previous coronary angiography, QCA: reduction in lumen-diameter of the vessel \>50%) with a scheduled intervention or operation to treat this stenosis (staged PCI or coronary artery bypass surgery)
- CMR feasible prior to intervention or surgery
- Age ≥18 years
- Written informed consent
- For healthy participants: Absence of cardiovascular and lung disease, and absence of medication with cardiovascular effects
- Absence of exclusion criteria
- Exclusion Criteria
- General Contraindication against MRI-Scans: (claustrophobia, ferromagnetic implants, clips, pacemakers, shrapnels, ophthalmic metal deposits)
- Pregnancy or inconclusive test result
- Age \<18 years
- Inability to give informed consent
- Consumption of caffeine, tea, treatment of dipyridamol \<12h before the scan
- Medication with calcium antagonists (ok, if can be paused on the day of the scan)
- Constant medication with nitrates (ok, if can be paused on the day of the scan)
- Medication with methyl-xanthines
- Acute myocardial ischemia/myocardial infarction
- Previous Coronary Bypass Surgery
- Pulmonary Disease
- Enrolment of the investigator, his/her family members, employees and other dependent persons
- Presence of cardiac or lung disease for healthy volunteers, nicotine consumption within the last 6 months
Exclusion
Key Trial Info
Start Date :
October 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 2 2017
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT02233634
Start Date
October 1 2014
End Date
November 2 2017
Last Update
December 15 2017
Active Locations (1)
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1
Bern University Hospital
Bern, Switzerland, 3010