Status:
COMPLETED
Insulinotropic Effect of GLP-1 and GIP After Dexamethasone
Lead Sponsor:
Hvidovre University Hospital
Conditions:
Type 2 Diabetes
Eligibility:
All Genders
20-45 years
Phase:
NA
Brief Summary
In this study we examine whether inducing insulin resistance by dexamethasone in healthy volunteers will lead to a decreased insulinotropic effect of the hormones GLP-1 and GIP.
Detailed Description
In this study we are going to examine the insulinotropic properties of GLP-1 and GIP before and after the development of insulin resistance and/or glucose intolerance.The insulinotropic properties of ...
Eligibility Criteria
Inclusion
- Caucasians above 20 and below 45 years of age
- Normal glucose tolerance as assessed by the WHO criteria
- First degree relative and at least 1 second degree relative with type 2 diabetes
- Normal haemoglobin
- Informed consent
Exclusion
- Liver disease (ALAT/ASAT \> 2 times normal value)
- Kidney disease (S-creatinin \> 130uM and/or albuminuria)
- Heart disease (NYHA II, III or IV)
- Treatment with medicine that cannot be paused
- Pregnancy of breast feeding
Key Trial Info
Start Date :
July 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT02235584
Start Date
July 1 2009
Last Update
September 10 2014
Active Locations (1)
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1
Bispebjerg University Hospital
Copenhagen NV, Denmark, 2400