Status:
COMPLETED
Frontal Cortex and Gait Freezing in Parkinson's Disease: Rehabilitation Impact
Lead Sponsor:
Oregon Health and Science University
Collaborating Sponsors:
US Department of Veterans Affairs
Conditions:
Parkinson's Disease
Eligibility:
All Genders
50-90 years
Phase:
NA
Brief Summary
This project will relate our new quantification of Freezing of Gait (FoG) in Parkinson's disease, using body worn inertial sensors (Aim I), with abnormalities in state-of-the-art, resting state, funct...
Eligibility Criteria
Inclusion
- Aged 50-90 years old.
- No musculoskeletal or peripheral or central nervous system disorders (other than idiopathic Parkinson disease, iPD) that could significantly affect balance or gait .
- Capable of following directions.
- iPD subjects: United Kingdom Brain Bank criteria, i.e., bradykinesia and at least one of the following: rest tremor, muscular rigidity, and postural instability not cause by visual, vestibular, cerebellar or proprioceptive dysfunction. Unilateral onset, response to levodopa.
Exclusion
- Inability to stand or walk for 2 min without an assistive device
- Recent changes in medication
- Excessive use of alcohol or recreational drugs,
- Contraindications to MRI scans (eg, claustrophobia, metal in body)
- Intervention subjects will be excluded if: 1) participating in a vigorous exercise program more than 2 x/week, 2) A medical condition that contraindicates exercise participation.
- Idiopathic PD subjects: Same as above and deep brain stimulation electrodes. Significant tremor that would interfere with MRI scan.
- Control subjects:
- Will be matched for age and gender to iPD group.
Key Trial Info
Start Date :
September 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2018
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT02236286
Start Date
September 1 2014
End Date
October 1 2018
Last Update
October 30 2018
Active Locations (1)
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1
VA Portland Health Care System (VAPORHCS)
Portland, Oregon, United States, 97239