Status:
COMPLETED
Clinical Trial of Air Cleaners to Improve Indoor Air Quality and COPD Health
Lead Sponsor:
Johns Hopkins University
Collaborating Sponsors:
National Institute of Environmental Health Sciences (NIEHS)
Conditions:
Chronic Obstructive Pulmonary Disease (COPD)
Eligibility:
All Genders
40+ years
Phase:
NA
Brief Summary
Objectives (include all primary and secondary objectives) Specific Aim #1: To determine whether an air cleaner intervention to improve home air quality will improve respiratory symptoms, quality of l...
Detailed Description
This research is being done to learn whether an air cleaner intervention to improve home air quality (particulate matter (PM) and nitrogen dioxide (NO2) reduction) will improve respiratory symptoms, q...
Eligibility Criteria
Inclusion
- Age ≥ 40 years,
- Physician diagnosis of COPD,
- Global Initiative for Obstructive Lung Disease (GOLD) Stage II-IV disease with Forced Expiratory Volume (FEV1)/ Forced Vital Capacity (FVC) ≤70% and FEV1 (% predicted) \<80%,
- Tobacco exposure ≥ 10 pack-years, and
- Former smoker. We will employ a combination of self-report and a biochemical marker to identify former-smokers. Exhaled CO (eCO) will be used as a marker of smoking status, as it is easy to perform, provides immediate data and is non-invasive. Former-smokers will be those who report no current smoking in the past 1 year AND have exhaled CO levels ≤ 6ppm. This threshold was chosen to maximize the chance of distinguishing true smokers and ex-smokers (\>95%).
Exclusion
- Chronic systemic corticosteroids (≥ 3 months continuous use in past 12 months),
- Other chronic lung disease including asthma,
- Living in location other than home (e.g., long term care facility) and
- Home owner or home occupant planning to move or change residence within the study period.
Key Trial Info
Start Date :
March 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 10 2021
Estimated Enrollment :
142 Patients enrolled
Trial Details
Trial ID
NCT02236858
Start Date
March 1 2014
End Date
September 10 2021
Last Update
September 14 2021
Active Locations (1)
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1
Johns Hopkins University
Baltimore, Maryland, United States, 21224