Status:
COMPLETED
Longitudinal Evaluation of HIV-associated Lung Disease Phenotypes
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Chronic Obstructive Pulmonary Disease
HIV
Eligibility:
All Genders
18-80 years
Brief Summary
The overall hypotheses of this proposal are that discrete phenotypes of HIV Chronic Obstructive Pulmonary disease (COPD) differ in their trajectories, biomarkers, and risk factors and that persistent ...
Detailed Description
The study is a multicenter, prospective observational study of pathogenesis of HIV pulmonary disease. We will determine the prevalence and risk factors for lung dysfunction as quantified by pulmonary ...
Eligibility Criteria
Inclusion
- HIV-1 infection, documented in medical record at any time prior to study entry.
- Men and women age 18 to 80.
- Ability and willingness to complete all tests.
- Participant in HLRC studies, MACS, Women's Interagency Health Study, and local HIV clinics.
- For UCSF only, new ART initiators from Women's Interagency Health Study or the HIV clinic
Exclusion
- Pregnancy or breast-feeding.
- Contraindication to pulmonary function testing (i.e. abdominal or cataract surgery within 3 months, recent myocardial infarction, etc.).
- Increasing respiratory symptoms or febrile (temperature \>100.40F \[380C\]) within 4 weeks of study entry.
- Hospitalization within 4 weeks prior to study entry (excluding mental health).
- Uncontrolled hypertension at screening visit (systolic \> 180 mm Hg or diastolic \> 100 mm Hg) from an average of two or more readings. Subject may return for screening after blood pressure is controlled.
- Active cancer requiring systemic chemotherapy or radiation.
- Active infection of lungs, brain, or abdomen.
- Intravenous drug use or alcohol use that will impair ability to complete study investigations in the opinion of the investigator
Key Trial Info
Start Date :
September 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 2 2020
Estimated Enrollment :
232 Patients enrolled
Trial Details
Trial ID
NCT02238327
Start Date
September 1 2014
End Date
March 2 2020
Last Update
October 8 2020
Active Locations (1)
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1
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213