Status:
COMPLETED
Screening Patients With Sickle Cell Disease for Kidney Damage
Lead Sponsor:
Children's Hospital Medical Center, Cincinnati
Conditions:
Sickle Cell Disease
Eligibility:
All Genders
Brief Summary
This study aims to study the temporal course of sickle nephropathy and assess novel biomarkers that can predict patients prone to nephropathy.
Detailed Description
Sickle cell disease causes kidney damage that gets worse with increasing age, leading to chronic kidney disease and kidney failure in nearly one third of patients with sickle cell disease. Some patien...
Eligibility Criteria
Inclusion
- Sickle cell disease (i.e. Hgb SS, Hgb SC, Sβ-Thalassemia)
- Individuals at baseline/steady state (absence of fever or acute sickle event, defined as vaso-occlusive pain crises, acute chest syndrome, splenic sequestration, stroke, priapism) for three weeks.
- Adult Subjects \> 18 years of age: ability to consent to donate blood and/or urine for research purposes only.
- Newborn to \< 18 years of age: ability of parent/legal guardian to consent for peripheral blood and/or urine samples to be obtained for research purposes only.
Exclusion
- Hematologic malignancy
- Patients that either do not have the ability to undergo the informed consent process or whose parent/legal guardian does not have the ability to undergo the informed consent process
Key Trial Info
Start Date :
April 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 29 2020
Estimated Enrollment :
320 Patients enrolled
Trial Details
Trial ID
NCT02239016
Start Date
April 1 2009
End Date
July 29 2020
Last Update
March 29 2021
Active Locations (4)
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1
Emory University (Children's Healthcare of Atlanta Pediatric Hospital)
Atlanta, Georgia, United States, 30322
2
Univeristy of Louisville (Kosair Children's Hospital)
Louisville, Kentucky, United States, 40202
3
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
4
Akron Childen's Hospital
Akron, Ohio, United States, 44308