Status:
COMPLETED
Dabigatran Etexilate for Secondary Stroke Prevention in Patients With Embolic Stroke of Undetermined Source (RE-SPECT ESUS)
Lead Sponsor:
Boehringer Ingelheim
Conditions:
Stroke
Secondary Prevention
Eligibility:
All Genders
18-150 years
Phase:
PHASE3
Brief Summary
This trial will enroll approximately 6,000 patients with recent embolic stroke of unknown source (ESUS). Patients will be randomized to dabigatran or acetylsalicyclic acid (ASA) (1:1 ratio) and have v...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Ischemic stroke with a brain lesion visualized by neuroimaging (either brain Computed Tomography (CT) or Magnetic Resonance Image (MRI)). The visualized stroke is a non-lacunar infarct , e.g. involving the cortex or \>1.5 cm (\>2.0 cm if measured on MRI diffusion-weighted images) in largest diameter if exclusively subcortical.Visualization by CT usually requires delayed imaging \>24-48 hours after stroke onset.
- The index stroke must have occurred either up to 3 months before randomization (Modified Rankin Scale(mRS) \<=3 at randomization) or up to 6 months before randomization (mRS \<=3 at randomization) in selected patients that are \>= 60 years plus at least one additional risk factor for recurrent stroke.
- Arterial imaging or cervical plus Transcranial Doppler (TCD) ultrasonography does not show extra-cranial or intracranial atherosclerosis with \>= 50% luminal stenosis in artery supplying the area of acute ischemia.
- As evidenced by cardiac monitoring for \>= 20 hours with automated rhythm detection, there is absence of AF \> 6 minutes in duration (within a 20 hour period, either as single episode or cumulative time of multiple episodes).
- Further inclusion criteria apply.
- Exclusion criteria:
- Modified Rankin Scale of \>=4 at time of randomization or inability to swallow medications.
- Major risk cardioembolic source of embolism such as: a) intracardiac thrombus as evidenced by transthoracic or transesophageal echocardiography, b) paroxysmal, persistent or permanent Atrial fibrillation (AF), c) atrial flutter, d) prosthetic cardiac valve (mitral or aortic, bioprosthetic or mechanical), e) atrial myxoma, f) other cardiac tumors, g) moderate or severe mitral stenosis, h) recent (\< 4weeks) myocardial infarction, i) valvular vegetations, or j) infective endocarditis.
- Any indication that requires treatment with an anticoagulant as per Investigator's judgment.
- History of atrial fibrillation (unless it was due to reversible causes such as hyperthyroidism or binge drinking, and has been permanently resolved).
- Other specific stroke etiology (i.e. cerebral arteritis or arterial dissection, migraine with aura/vasospasm, drug abuse).
- Renal impairment with estimated creatinine clearance (as calculated by Cockcroft-Gault equation) \<30mL/min at screening, or where Investigator expects creatinine clearance is likely to drop below 30mL/min during the course of the study.
- Further exclusion criteria apply.
Exclusion
Key Trial Info
Start Date :
November 27 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 14 2018
Estimated Enrollment :
5390 Patients enrolled
Trial Details
Trial ID
NCT02239120
Start Date
November 27 2014
End Date
August 14 2018
Last Update
September 6 2019
Active Locations (569)
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1
Bronislava Shafran, MD PC
Phoenix, Arizona, United States, 85006
2
Westside Medical Associates of Los Angeles
Beverly Hills, California, United States, 90211
3
TriWest Research Associates, LLC
El Cajon, California, United States, 92020
4
University of California
Fresno, California, United States, 93721