Status:
COMPLETED
Hemo Filtration Reinfusion (HFR) Clearance Efficiency Towards P-bound Toxins and Effects on Inflammatory and Endothelial Damage Markers
Lead Sponsor:
Hospital Universitario Reina Sofia de Cordoba
Conditions:
Inflammation
Eligibility:
All Genders
18+ years
Brief Summary
The aim of this study is to compare purification efficiency of HFR in terms of clearance of protein-bound toxins and the effects on markers of inflammation and endothelial damage, in comparison to HF-...
Detailed Description
Protein-bound uremic toxins are poorly removed by current dialysis techniques because of their size, which is larger than the pore size of dialysis membranes available in the market. These protein-bou...
Eligibility Criteria
Inclusion
- Stable patients on hemodialysis for al least 3 month
- older than 18 year old
- dialyzed at least for two months with a high-flux membrane permeability
- arteriovenous fistula with high blood flow (\> 350 ml / min)
Exclusion
- active neoplasia
- positive viral markers (HBsAg, anti-HCV and HIV),
- clinical signs of active infection and/or inflammation,
- albumin \< 3.5 g/dl.
Key Trial Info
Start Date :
May 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2015
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT02240004
Start Date
May 1 2014
End Date
March 1 2015
Last Update
March 30 2015
Active Locations (1)
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1
HU Reina Sofia
Córdoba, Spain