Status:
UNKNOWN
Phase I Study of an Oncofetal Antigen Multi-Peptide Immunotherapy in Subjects With Hematologic Cancer
Lead Sponsor:
Benovus Bio, Inc.
Conditions:
Acute Myelogenous Leukemia (AML)
Multiple Myeloma (MM)
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
The study is designed to evaluate safety, immunogenicity, and preliminary anti-tumor activity of a multi-peptide immunotherapy (BB-MPI-03) at three peptide+adjuvant dose levels. The peptides stimulate...
Detailed Description
The current study is a Phase I, open-label, multi-center, dose escalation study designed to evaluate safety, immunogencity, and potential anti-tumor activity of BB-MPI-03 at three peptide plus adjuvan...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- a. History of morphologically confirmed AML w/ classification other than WHO Acute Promyelocytic Leukemia (FAB M3), based on bone marrow examination.
- i. not a candidate for allogeneic HSCT or no intention to move to HSCT at time of enrollment.
- ii. Patient's AML could be in morphologic CR or no further cytotoxic chemotherapy is currently being considered.
- iii. Completed consolidation chemotherapy, if available and/or appropriate for patient.
- iv. Can have history of allogeneic HSCT transplant, but must be off immunosuppression for at least 2 wks. before enrollment and w/o GVHD and/or toxicities from HSCT.
- b. Diagnosed in past 5 years w/ smoldering MM at high risk of progressing to symptomatic MM.
- i. Diagnosis defined as: Bone marrow infiltration with plasma cells (PCs) ≥10% and presence of a monoclonal component, Ig G ≥3 g/dl or IgA ≥2 g/dl or Bence-Jones proteinuria \>1 g/dl and absence of lytic lesions on skeletal survey, absence of hypercalcemia (corrected calcium \<11 mg/dl), absence of renal failure (creatinine ≤1.5 x ULN), and absence of anemia (hemoglobin \>10 g/dl or not 2 g/dl below LLN).
- ii. Must meet one of following:
- ≥10% PCs in bone marrow and IgG ≥3 g/dl or IgA ≥2 g/dl,
- ≥10% PCs in bone marrow and serum FLC ratio (involved : uninvolved) \>100 in blood, or
- IgG ≥3 g/dl or IgA ≥2 g/dl and FLC ratio (involved: uninvolved) \>100 in blood. c. MM post-treatment disease that is clinically stable and does not require treatment at least 4 weeks prior to enrollment.
- i. At least one line of treatment and achieved at least PR by IMWG ii. Stable disease or better per IMWG based on 2 subsequent assessments at least one month apart d. history of morphologically confirmed MDS i. previously received at least one treatment for MDS, including but not limited to chemotherapy or hypomethylating agent(s). Subjects may be previously untreated if they refuse treatment with or are not appropriate candidates for chemotherapy or hypomethylating agent(s) in the investigator's opinion.
- ii. intermediate, high, or very high risk MDS by IPSS-r iii. No curative intent option of allogeneic HSCT or refused consideration for allogeneic HSCT iv. Could have history of allogeneic HSCT transplant and relapsed, but must be off immunosuppression for at least 2 weeks before enrollment and without GVHD and/or toxicities from HSCT.
- 2\. Low, moderate, to high levels of OFA expression by IHC analysis of tumor specimens.
- 3\. HLA-A\*02 haplotype.
- 4\. ECOG performance status 0 to 2.
- 5\. 18 years or older.
- 6\. life expectancy ≥3 months.
- 7\. Has following laboratory parameters w/in 28 days:
- ANC ≥500/mm3
- ALC \>500/mm3
- PLT ≥25,000/mm3 and may be transfused
- Hgb \>8 g/dL (may have been transfused)
- Serum creatinine ≤1.5 x ULN
- Total bilirubin ≤2.0 mg/dL, unless elevated bilirubin due to Gilbert's syndrome
- ALT and AST less than 5×ULN
- 8\. If female of child-bearing potential, negative serum pregnancy test result w/in 28 of D1 and agree to abstain from heterosexual intercourse or use acceptable method of birth control (hormonal or barrier method) from Screening through 30 days after last dose
- 9\. If male having sexual contact with a female of child-bearing potential, agrees to use a latex condom dor agrees to ensure partner uses an acceptable method of birth control (hormonal or barrier method)from Screening through 30 days after last dose
- 10\. Able to provide written informed consent
- Exclusion Criteria
- Received chemotherapy, biological therapy, or radiation therapy less than one month before D1
- No prior history of active CNS involvement
- Grade 2 or higher peripheral neuropathy w/in 28 days
- Acute promyelocytic leukemia (FAB M3)
- Other active systemic malignancy treated w/ cytotoxic chemotherapy in previous 12 mos.
- Monoclonal gammopathy of undetermined significance
- For smoldering MM, baseline bone lesions or plasmacytomas
- For smoldering MM, lytic lesions on skeletal surveys and hypercalcemia (i.e., ≥11 mg/dL)
- Known HIV or hepatitis virus infection
- Active infection requiring antibiotics
- History of prior or active autoimmune disease such as Lupus or rheumatoid arthritis
- Significant kidney or liver disease, uncontrolled severe cardiovascular or pulmonary disease, other uncontrolled medical condition that would compromise subject's ability to tolerate study treatment
- Received any investigational treatment w/in 30 days
- Receiving systemic glucocorticosteroid \>10 mg daily. Concurrent use after registration on study should be restricted to equivalent of prednisone 10 mg per day. Prior or concurrent topical or localized glucocorticosteroid therapy to treat non-malignant comorbid disorders is permitted. Subject requiring routine use of steroid inhalers are not eligible.
- Major surgery w/in 4 wks.
- G-CSF w/in 30 days
Exclusion
Key Trial Info
Start Date :
January 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2017
Estimated Enrollment :
4 Patients enrolled
Trial Details
Trial ID
NCT02240537
Start Date
January 1 2015
End Date
June 1 2017
Last Update
April 19 2016
Active Locations (3)
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1
University of Chicago
Chicago, Illinois, United States, 60637
2
University of Michigan
Ann Arbor, Michigan, United States, 48109
3
Virginia Cancer Specialists
Fairfax, Virginia, United States, 22031