Status:
TERMINATED
Kappa Opioid Receptor Imaging in Anorexia
Lead Sponsor:
NYU Langone Health
Collaborating Sponsors:
Yale University
Icahn School of Medicine at Mount Sinai
Conditions:
Anorexia Nervosa
Eligibility:
FEMALE
18-55 years
Brief Summary
The purpose of this study is to use positron emission tomography (PET) imaging and magnetic resonance imaging (MRI) to understand the brain function of individuals with anorexia nervosa and healthy co...
Detailed Description
This is a 3-year study involving n=7 women with anorexia nervosa - recovered (AN-REC) from restricting subtype that have achieved a body mass index (BMI) \> 18.5 in the past year, are medication free,...
Eligibility Criteria
Inclusion
- Inclusion criteria for anorexic patients:
- Able to understand the consent form document
- A willingness to participate in a psychiatric evaluation, collection of behavioral ratings and neuroendocrine assessments, and imaging studies including 1 PET scan and 1 MRI scan
- Meets criteria for Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) Anorexia Nervosa (AN)
- Subjects will be between 18 and 55 years of age
- Currently weight restored with a body mass index (BMI) \> 18.5 for longer than 3 months
- Inclusion criteria for healthy controls:
- Able to understand the consent form document
- A willingness to participate in a psychiatric evaluation, collection of behavioral ratings and neuroendocrine assessments, and imaging studies including 1 PET scan and 1 MRI scan
- Subjects will be between 18 and 55 years of age
- Regular menstruation and no personal or first-degree family history of any Axis I diagnosis based on DSM-IV criteria
- Exclusion criteria for anorexic patients:
- Any major neurological illness or injury
- Presence of any legal or illegal psychoactive substances determined with urine toxicology, and breathalyzer test for alcohol
- Any significant unstable medical condition such as asthma or heart disease which may limit the interpretation of the imaging results, for example due to changes in tracer delivery in hypertensive patients
- Intelligence quotient (IQ)\<70 based on past intelligence
- Any metal in body that would pose a risk with MRI
- Claustrophobia that would interfere with MRI or PET imaging
- Currently pregnant or nursing
- Exclusion criteria for healthy controls:
- Any major neurological illness or injury
- Presence of any legal or illegal psychoactive substances determined with urine toxicology, and breathalyzer test for alcohol
- Any significant unstable medical condition such as asthma or heart disease which may limit the interpretation of the imaging results, for example due to changes in tracer delivery in hypertensive patients
- IQ\<70 based on past intelligence
- Any metal in body that would pose a risk with MRI
- Claustrophobia that would interfere with MRI or PET imaging
- Currently pregnant or nursing
Exclusion
Key Trial Info
Start Date :
September 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2016
Estimated Enrollment :
7 Patients enrolled
Trial Details
Trial ID
NCT02240797
Start Date
September 1 2014
End Date
March 1 2016
Last Update
August 17 2016
Active Locations (1)
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1
NYU School of Medicine
New York, New York, United States, 10016