Status:
UNKNOWN
MSCs With or Without Peripheral Blood Stem Cell for Treatment of Poor Graft Function and Delayed Platelet Engraftment
Lead Sponsor:
Nanfang Hospital, Southern Medical University
Collaborating Sponsors:
Guangdong Provincial People's Hospital
Third Affiliated Hospital, Sun Yat-Sen University
Conditions:
Stem Cell Transplantation, Hematopoietic
Poor Graft Function
Eligibility:
All Genders
14-65 years
Phase:
PHASE2
PHASE3
Brief Summary
The purpose of this study is to compare the efficacy of mesenchymal stem cells (MSCs) with or without granulocyte colony-stimulating factor (G-CSF) mobilized peripheral stem cells (PBSC) in treating p...
Detailed Description
Allogeneic hematopoietic stem cell transplantation(allo-HSCT) is the only cure for many hematologic diseases. However, about 5-27% of patients would suffer from poor graft function (PGF) and more reci...
Eligibility Criteria
Inclusion
- Age：14-65 years
- PGF or DPE after allo-HSCT
- Subjects (or their legally acceptable representatives) must have signed an informed consent document
Exclusion
- Any abnormality in a vital sign (e.g., heart rate, respiratory rate, or blood pressure)
- Patients with any conditions not suitable for the trial (investigators' decision)
Key Trial Info
Start Date :
September 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2018
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT02240992
Start Date
September 1 2014
End Date
December 1 2018
Last Update
September 16 2014
Active Locations (1)
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1
Department of Hematology,Nanfang Hospital, Southern Medical University
Guangzhou, Guangdong, China, 510515