Status:
COMPLETED
Laparoscopic Hepatectomy and Radiofrequency Ablation in the Treatment of Early Hepatocellular Carcinoma
Lead Sponsor:
ChenJian
Conditions:
Hepatocellular Carcinoma
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
The purpose of this research is to compare short-term and long-term efficacy of laparoscopic hepatectomy and radiofrequency ablation in the Treatment of early hepatocellular carcinoma, and provide the...
Detailed Description
Background:The aim of this study was to compare the efficacy of laparoscopic hepatectomy(LH) with radiofrequency ablation (RFA) in the treatment of early hepatocellular carcinoma (HCC). Methods:A tot...
Eligibility Criteria
Inclusion
- Any gender,18 to 70 years old;
- Preoperative diagnosis of primary liver clear;
- No active hepatitis and decompensated cirrhosis;
- Maximum diameter ≤3cm single nodules or three nodules in diameter and no more than 3cm,did not infringe the portal vein,hepatic vein and inferior vena cava invasion,lymph node or extrahepatic turn;
- No tumor rupture or bleeding;
- Child-Pugh class A or B grade,ICG-R15 \<14%;
- No coagulation disorders,platelet count \> 50 × 109 / L and prolonged prothrombin time \< 5 seconds;
- Not be including related surgery,radiofrequency ablation (RFA),TACE treatment,no certainty anticancer chemotherapy treatment;supreme absolute contraindications abdominal surgery;
- Patients generally available,heart and lung function can tolerate surgery, abdominal surgery supreme absolute contraindications;
- Voluntarily participate in the study,informed consent.
Exclusion
- Age \< 18 years or \> 70,pregnant and lactating women;
- Primary liver cancer diagnosis is not clear
- Liver function assessment:Child-PughC level,liver function reserve situation :ICGR-15\> 14%
- Tumor rupture has occurred,or has the line before surgery,radiofrequency ablation (RFA),TACE or chemotherapy cancer treatment;
- Tips liver imaging with multiple ( \> 3 ) lesion,or tumor diameter\> 3 cm, clear portal vein,hepatic vein,inferior vena cava tumor thrombus trunk;
- Preoperative liver metastasis;
- Preoperative evaluation of cardiopulmonary dysfunction patients who can not tolerate surgery;
- Intraoperative exploration has occurred disseminated tumor and / or lymph node metastasis;
- Exploratory surgery found that non-hepatic primary tumors,such as colorectal metastases,hilar cell carcinoma;
- Severe upper abdominal adhesions;
- Postoperative pathological examination of the bile duct cell or mixed cell carcinoma and pathologically confirmed positive margin;
- Foreign,Hong Kong,Macao,Taiwan and other regions,estimated postoperative difficult to track,followed up.
Key Trial Info
Start Date :
September 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2021
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT02243384
Start Date
September 1 2014
End Date
October 1 2021
Last Update
June 2 2022
Active Locations (1)
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1
JianChen
Chongqing, Chongqing Municipality, China, 400038