Status:
UNKNOWN
Intravascular Ultrasound Evaluation of Renal Nerves in Different Diseases
Lead Sponsor:
The Second Affiliated Hospital of Chongqing Medical University
Conditions:
Hypertension
Heart Failure
Eligibility:
All Genders
18+ years
Brief Summary
Sympathetic hyperactivity is a causal or a promoting factor in many diseases, under these conditions, some morphology changes due to the hyperactivity occur. Renal nerve is an important part in the au...
Detailed Description
People eligible for this study will be divided into 4 groups according to the eligibility criteria(Resistant Hypertension Group,Essential Hypertension Group, Chronic Heart Failure Group and Control Gr...
Eligibility Criteria
Inclusion
- Resistant hypertension group
- blood pressure remains above goal in spite of the concurrent use of three or more anti-hypertensive agents(including a diuretic) at adequate doses.
- agrees to have the study procedure(s) performed and additional procedures and evaluations
- Essential hypertension group
- systolic blood pressure ≥ 140 mmHg, diastolic blood pressure ≥ 90 mmHg, or current use of anti-hypertensive medication with a normal blood pressure or mean ambulatory blood pressure during the 24-hour≥130/80 mmHg.
- not resistant to pharmacotherapy.
- agrees to have the study procedure(s) performed and additional procedures and evaluations
- Chronic heart failure group
- New York Heart Association class II-III symptoms, or American College of Cardiology(ACC) / American Heart Association(AHA) heart failure classification B-C class of chronic heart failure.
- currently or prior have the signs of heart failure, such as elevated jugular venous pressure, peripheral edema, pulmonary crepitations, ect.
- Systolic left ventricular dysfunction as assessed by echocardiogram with left ventricular ejection fraction \< 40%.
- agrees to have the study procedure(s) performed and additional procedures and evaluations
- Control group
- no history of arterial hypertension, heart failure and diabetes
- going to take a vascular interventional examination during hospitalization
- agrees to have the study procedure(s) performed and additional procedures and evaluations
- All patients have full capacity for civil conduct and agree to sign the Medical Informed Consent.
Exclusion
- hemodynamically or anatomically significant renal artery stenosis.
- renal artery variation.
- renal artery diameter \< 4 mm, trunk length \< 20 mm.
- secondary hypertension with known causes and pseudo-hypertension.
- has experienced myocardial infarction, unstable angina pectoris, or cerebrovascular accident within 6 months.
- has an implantable cardioverter defibrillator (ICD) or pacemaker.
- requires respiratory support.
- is pregnant or planning to be pregnant.
- cardiovascular diseases with sever hemodynamic disorder.
- type 1 diabetes mellitus.
- currently enrolled in another investigational drug or device trial.
- civil disability or limited capacity for civil conduct.
- other conditions researchers considered unsuitable for enrolled in the trial.
Key Trial Info
Start Date :
October 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2015
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT02243514
Start Date
October 1 2014
End Date
May 1 2015
Last Update
October 23 2014
Active Locations (1)
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1
The 2nd Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China, 400010