Status:
WITHDRAWN
Effects of Growth Hormone (GH) Deficiency and Growth Hormone Replacement on Serum Fibroblast Growth Factor 21 (FGF21)
Lead Sponsor:
University of Liverpool
Collaborating Sponsors:
Pfizer
Conditions:
Growth Hormone Deficiency
Eligibility:
All Genders
18-80 years
Brief Summary
This study will recruit healthy controls (who have normal GH production and growth hormone levels) and patients identified as having GHD, who are deemed eligible for GH replacement therapy according t...
Detailed Description
Growth hormone (GH) is involved in controlling people's general health and an underproduction of growth hormone (growth hormone deficiency or GHD) leads to people feeling generally unwell and having a...
Eligibility Criteria
Inclusion
- All evaluations to determine eligibility into the study and for growth hormone replacement are performed as part of routine clinical care. It should be emphasised that no research specific screening tests will be performed. Patients deemed eligible for entry into study, who decline to participate in the research, will still be commenced on growth hormone in line routine clinical care.
- Inclusion criteria: Patients with confirmed GH deficiency who are deemed eligible for GH replacement as assessed by the AGHDA QOL questionnaire.
- Exclusion criteria: Claustrophobia or having significant metal work is a contra-indication to MRI scanning.
- Withdrawal criteria: Patients will be withdrawn from the study if they discontinue their growth hormone replacement therapy for any clinical reason.
Exclusion
Key Trial Info
Start Date :
September 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 6 2017
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT02243852
Start Date
September 1 2014
End Date
June 6 2017
Last Update
December 18 2024
Active Locations (2)
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1
MARIARC
Liverpool, Merseyside, United Kingdom, L69 3GE
2
University Hospital Aintree
Liverpool, Merseyside, United Kingdom, L9 7AL