Status:
COMPLETED
Right Ventricular Hemodynamics Using Cardiac MRI in Patients COPD and OSA
Lead Sponsor:
University of California, San Diego
Conditions:
Obstructive Sleep Apnea
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
The coexistence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) in the same patient has been termed overlap syndrome, affecting 1% of the U.S. population.The investig...
Detailed Description
Despite the high prevalence of overlap syndrome, few data are available on its pathophysiology and clinical consequences of these patients. Overlap syndrome has recently been reported to have excess c...
Eligibility Criteria
Inclusion
- Both men and women with age more than 18 years.
- Known diagnosis of stable COPD (GOLD stage 2 or higher) or OSA.
Exclusion
- Already using continuous positive airway pressure (CPAP), BPAP device, or nocturnal oxygen.
- Known or suspected renal failure with estimated Glomerular filtration (GFR) \<50 ml/min/1.73 m2 or serum creatinine \> 1.5 mg/dl.
- Chronic atrial fibrillation or frequent premature ventricular contraction (\> 10 beats per hour)
- Women known to be pregnant or planning to be pregnant in next 6 months.
- Known contraindication to MRI: cardiac pacemaker, metallic heart valves, metallic implants, history of claustrophobia.
- If taking sildenafil or related drugs, unable to stop it within 48 hours of the study visit.
- Uncontrolled COPD or acute COPD exacerbation.
- Unstable cardiac diseases.
- Known chronic inflammatory diseases like lupus or active infection.
Key Trial Info
Start Date :
September 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2020
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT02244957
Start Date
September 1 2014
End Date
February 1 2020
Last Update
July 28 2020
Active Locations (1)
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1
University of California, San Diego
San Diego, California, United States, 92093