Status:
COMPLETED
Cone Rescue in Retinitis Pigmentosa by the Treatment of Lycium Barbarum
Lead Sponsor:
The Hong Kong Polytechnic University
Collaborating Sponsors:
The University of Hong Kong
Conditions:
Retinitis Pigmentosa
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Objectives: To study the immediate effect and the persistent effect of Lycium barbarum (LB) treatment on retinal functions, especially the cone function, and retinal structure in patients with retinit...
Detailed Description
The study was a randomized controlled trial with a double-masked, placebo-controlled design. All the subjects were randomly allocated into either LB (treatment) group or placebo (control) group. All ...
Eligibility Criteria
Inclusion
- Ocular conditions:
- Retinitis pigmentosa;
- best corrected VA LogMAR 0.20 or better;
- Humphrey Visual Field Analysis (HVFA) 30-2 total mean defect \> or = 250 Decibel;
- Intra-ocular pressure (IOP) \<21 mmHg;
- van Herrick ratio \< or = 0.5;
- no other ocular diseases
- Dietary conditions:
- Fruit and vegetable intake \<10 servings/day;
- spinach or kale intake \< or = serving/day;
- dietary lutein intake \< or = 5.4mg/day;
- no intake of cod liver oil or omega-3 capsules;
- dietary Lycium barbarum intake \< or =10 fruits/week;
- supplement intake \< or = 5000 IU/day of Vit. A and \< or = 30 IU/day of Vit. E;
- alcoholic consumption \< or = 3 beverages/day
Exclusion
- BMI \> 40;
- intake of any anticoagulants (especially Warfarin),
- pregnant or planning to be pregnant;
- smoking;
- other clinically significant systemic diseases, eg. diabetes, liver disease and heart disease
Key Trial Info
Start Date :
November 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2017
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT02244996
Start Date
November 1 2014
End Date
November 1 2017
Last Update
February 19 2019
Active Locations (1)
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1
The Hong Kong Polytechnic University
Hong Kong, Hong Kong