Status:
COMPLETED
Circulating Tumor DNA in Predicting Outcomes in Patients With Stage IV Head and Neck Cancer or Stage III-IV Non-small Cell Lung Cancer
Lead Sponsor:
Sidney Kimmel Cancer Center at Thomas Jefferson University
Conditions:
Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma
Salivary Gland Squamous Cell Carcinoma
Eligibility:
All Genders
18+ years
Brief Summary
This pilot research trial studies circulating tumor deoxyribonucleic acid (DNA) in predicting outcomes in patients with stage IV head and neck cancer or stage III-IV non-small cell lung cancer. Studyi...
Detailed Description
PRIMARY OBJECTIVES: I. To evaluate the predictive value of the circulating tumor DNA for disease-free survival/progression-free survival in patients with advanced head and neck carcinoma (HNC) and no...
Eligibility Criteria
Inclusion
- Patients older than 18 years age
- Diagnosis of advanced HNC (Stage III, IVA, IVB, IVC) or NSCLC (Stage IIA, IIB, IIIA, IIIB, IV) (patients with synchronous advanced HNC and NSCLC are eligible)
- ECOG performance status score of 0-3
- Life expectancy of 3 months or longer
- Patients able to provide a written informed consent prior to study entry
Exclusion
- Prior chemotherapy or full course of radiotherapy for their present advanced HNC or NSCLC
- Patients are excluded if they have a history of any other malignancy from which the patient has been disease-free for less than 2 years, with the exception of adequately treated basal or squamous cell carcinoma of skin
- Other severe acute or chronic medical or psychiatric condition that may increase the risk associated with study participation, and in the judgment of the investigator would make the subject inappropriate for entry into this study
Key Trial Info
Start Date :
July 22 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 8 2023
Estimated Enrollment :
130 Patients enrolled
Trial Details
Trial ID
NCT02245100
Start Date
July 22 2014
End Date
December 8 2023
Last Update
May 15 2025
Active Locations (1)
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1
Thomas Jefferson University
Philadelphia, Pennsylvania, United States, 19107