Status:
COMPLETED
Phase I Studies of Chlorogenic Acid for Injection for Tolerance and Pharmacokinetic of Advanced Cancers
Lead Sponsor:
Sichuan J.Z. Bio-chemical Science and Technology Development Co., Ltd
Collaborating Sponsors:
Peking University Cancer Hospital & Institute
Conditions:
Advanced Cancer
Eligibility:
All Genders
18-65 years
Phase:
PHASE1
Brief Summary
The purpose of this study: Determining the Maximum Tolerated Dose (MTD), Dose-Limiting Toxicity (DLT), pharmacokinetics characteristic, and dosage regimen of phase II/III of Chlorogenic acid for inje...
Detailed Description
1. Investigate the tolerance of Chlorogenic acid for injection in human body, determine the Maximum Tolerated Dose (MTD) and Dose-Limiting Toxicity (DLT) of Chlorogenic acid for injection in the advan...
Eligibility Criteria
Inclusion
- Patients with pathologic or/and FNAC confirmation of advanced cancer but without effective treatment or with treatment failure;
- Between 18 and 65 years of age, KPS≥70;
- According to RECIST 1.1,patients with at least one tumor lesion that can accurately be measured by CT or MRI in at least one dimension with longest diameter to be recorded as \>2.0cm by general CT or \>1.0cm by spiral CT;
- Life expectancy of at least three (3) months at the enrollment;
- Patients who have sufficient baseline organ function and whose laboratory data can meet the following criteria at the enrollment:
- PLT count≥100×10\~9/L,
- WLB count≥4.0×10\~9/L and ≤12×10\~9/L,
- Neutrophil granulocyte count≥2.0×10\~9/L,
- HGB count≥90g/L,
- Total bilirubin \<=1.5 times of ULN,
- ALT/AST ≤2.5 times of ULN,
- SCr≤1.5 times of ULN,
- Normal ECG with LVEF (≥50%) measured by echocardiography;
- Female patients with negative pregnant test, and male/female patients of reproductive age without pregnancy planning in the next 12 months;
- Volunteered for the phase 1 trial and sign the informed consent without protest;
Exclusion
- Patients who have received large area radiotherapy （\>30% marrow capacity）;
- Patients who suffer from other serious complication, such as uncontrollable infection, myocardial infarction within the past 6 months at the enrollment , uncontrollable hypertension ,thromboembolism and etc.;
- Symptomatic patients with brain metastases (except for the patients whose brain metastases is controlled to stable status after whole brain radiotherapy);
- Patients who have received the therapy of chemotherapy within 4 weeks before enrollment;
- Patients who have used nitrosoureas drug or mitomycin within 6 weeks or tyrosine kinase inhibitor within 2 weeks before enrollment;
- Patients who have received therapy of major surgery within 6 weeks or biopsy surgery within 2 weeks before enrollment;
- Patients who or have received radical radiotherapy within 6 weeks or local palliative radiotherapy within 2 weeks before enrollment;
- Patients who experience grade 2 or more than grade 2 toxicity caused by the past therapies;
- Patients who have history of drug abuse or alcoholism;
- Patients who smoke over 5 cigarettes or equivalent tobacco per day;
- Uncontrollable psychopaths;
- Pregnant or breast-feeding women, or patients(male and female) who have pregnancy plan;
- Patients who had received a therapy of another investigational drug within 4 weeks or patients who are still in another clinical trial at the enrollment;
- Known active hepatitis B/hepatitis C, positive HIV/ syphilis antibody;
- Patient who need long term treatment of cortical hormone or other immunosuppressive drugs such as visceral organ transplanters;
- Allergic to the investigational drug;
- Other patients judged ineligible for enrollment in the study by the investigator (sub-investigator).
Key Trial Info
Start Date :
September 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2016
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT02245204
Start Date
September 1 2014
End Date
October 1 2016
Last Update
November 21 2018
Active Locations (1)
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1
Beijing Cancer Hospital
Beijing, China, 100142