Status:
RECRUITING
Screening for Synchronous Metastases in Colorectal Cancer With DW-MRI (SERENADE)
Lead Sponsor:
Imperial College London
Collaborating Sponsors:
Pelican Cancer Foundation
Conditions:
Colorectal Neoplasms
Neoplasm Metastases
Eligibility:
All Genders
16+ years
Phase:
NA
Brief Summary
Eligible patients with high risk colorectal malignancy (T3/4, spread greater than 5mm, EMVI positive) will have additional surveillance of breath hold T1, T2 and DW-MRIs (no IV contrast) post surgery ...
Detailed Description
A phase II multicentre, interventional study to determine if additional staging at diagnosis with liver DW-MRI will diagnose more synchronous metastases than CT alone in patients with high risk colore...
Eligibility Criteria
Inclusion Criteria:
- Have a high risk primary colorectal malignancy
- Have a negative CT or includes no confirmatory evidence of liver metastases
- Is able to undergo treatment if liver metastasis is found
- Have provided written informed consent to participate in the study
- Be aged 16 years or over
Exclusion Criteria:
- Have had a previous colorectal malignancy
- Have metastatic disease
- Have a synchronous second malignancy
- Are contraindicated for MRI
- Has a T3b or below low rectal tumour without EMVI or N1c
Key Trial Info
Start Date :
August 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2031
Estimated Enrollment :
282 Patients enrolled
Trial Details
Trial ID
NCT02246634
Start Date
August 1 2014
End Date
December 1 2031
Last Update
October 17 2024
Active Locations (13)
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1
Macclesfield District General Hospital
Macclesfield, Cheshire, United Kingdom, SK10 3BL
2
Queen's Hospital
Burton-on-Trent, Derbyshire, United Kingdom, DE13 0RB
3
Broomfield Hospital
Chelmsford, Essex, United Kingdom, CM1 7ET
4
Royal Bolton Hospital
Bolton, Greater Manchester, United Kingdom, BL4 0JR