Status:
COMPLETED
Pupil Response in Patients on Opioids.
Lead Sponsor:
Oslo University Hospital
Conditions:
Chronic Pain
Impaired Pupillary Reflex
Eligibility:
All Genders
18+ years
Brief Summary
Evaluation of pupillary reflex in patients on high-dose opioids. Clinical assessment of pain intensity, sedation score, and other side effects of opioids. Measurements of the concentration of opioids ...
Detailed Description
Pupil size reflects the balance between sympathetic and parasympathetic systems. Pupil size and reaction are also influenced by drugs, where opioids result in miosis, an effect that is not considered ...
Eligibility Criteria
Inclusion
- In-patients and out-patients at Oslo University Hospital with cancer pain who have use opioids (morphine, oxycodone, fentanyl or methadone or a combination of these drugs) at least for periods of 4 weeks, and use opioids corresponding to at least 60 mg oral morphine equivalents pr day
Exclusion
- Patients who have undergone eye-surgery that may influence pupillary reflexes
- Patients on local medication that may influence pupillary reflexes
- Patients with amyloidosis, multiple sclerosis, Horner's syndrome, or ongoing migraine attack
- Patients with brain tumor
Key Trial Info
Start Date :
January 1 2015
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2018
Estimated Enrollment :
63 Patients enrolled
Trial Details
Trial ID
NCT02247024
Start Date
January 1 2015
End Date
November 1 2018
Last Update
January 29 2019
Active Locations (2)
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1
Oslo University Hospital, The Norwegian Radium Hospital
Oslo, Norway, 0310
2
The Norwegian Radium Hospital
Oslo, Norway, 0310