Status:
COMPLETED
Patient-derived Xenograft (PDX) Modeling of Treatment Response for Triple Negative Breast Cancer
Lead Sponsor:
Icahn School of Medicine at Mount Sinai
Collaborating Sponsors:
Champions Oncology
Conditions:
Triple Negative Breast Cancer
Eligibility:
All Genders
18-90 years
Brief Summary
This study will determine if patient-derived tumor xenograft (PDX) mouse models can serve as a reliable model for treatment response for individual patients with triple negative breast cancer. The col...
Detailed Description
Triple negative breast cancer (TNBC) represents an aggressive, genomically heterogeneous, subtype of breast cancer with limited therapeutic options. Many patients with TNBC receive standard neoadjuvan...
Eligibility Criteria
Inclusion
- a histological diagnosis of invasive triple negative breast cancer determined by standard immunohistochemical analysis.
- must be candidates for neoadjuvant chemotherapy according to standard of care guidelines or have evidence of metastatic disease.
- must agree to a biopsy for research purposes at time of diagnosis and to undergo surgery at the hospitals of the Mount Sinai Health System.
- Patients with the following MAY be eligible:
- \- a histological diagnosis of ER and/or PR positive breast cancer with an overall receptor expression ≤ 30% breast cancer determined by standard immunohistochemical analysis
Exclusion
- concurrent disease or condition that would make the patient inappropriate for study participation,
- any serious medical or psychiatric disorder that would interfere with the subject's safety, or inability to provide informed consent.
- vulnerable populations will not be included.
Key Trial Info
Start Date :
July 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 22 2019
Estimated Enrollment :
68 Patients enrolled
Trial Details
Trial ID
NCT02247037
Start Date
July 1 2014
End Date
January 22 2019
Last Update
July 7 2020
Active Locations (1)
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1
Dubin Breast Center of The Tisch Cancer Institute at Mount Sinai
New York, New York, United States, 10029