Status:
ACTIVE_NOT_RECRUITING
Plasma microRNA Profiling as First Line Screening Test for Lung Cancer Detection: a Prospective Study
Lead Sponsor:
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Conditions:
Lung Cancer
Eligibility:
All Genders
50-75 years
Phase:
NA
Brief Summary
In the present project we propose a large prospective study in heavy smokers volunteers based on plasma miRNA profiling to assess its efficacy as a first line screening test for lung cancer detection....
Detailed Description
Three decades of research have shown that radiological screening of heavy smokers can detect resectable early lung cancers with higher frequency but benefit on mortality is still debated. The prelimin...
Eligibility Criteria
Inclusion
- current heavy smokers of ≥ 30 pack/years, aged 50-75, or former smokers with the same smoking habits having stopped from 10 years or less;
- current or former smokers of \< 30 pack/years, aged ≥ 50, with additional risk factors such as family history of lung cancer, prior diagnosis of chronic obstructive pulmonary disease (COPD) or pneumonia, professional exposure to known carcinogens (i.e. asbestos).
Exclusion
- subjects with neoplasms within previous five years-
- subjects with suspected lung nodules under investigation
Key Trial Info
Start Date :
January 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2026
Estimated Enrollment :
4119 Patients enrolled
Trial Details
Trial ID
NCT02247453
Start Date
January 1 2013
End Date
October 1 2026
Last Update
March 7 2024
Active Locations (1)
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1
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Italy, 20133