Status:
COMPLETED
Effects of High-Dose Resveratrol in Non-Diabetic Obese Males
Lead Sponsor:
Khoo Teck Puat Hospital
Collaborating Sponsors:
National Medical Research Council (NMRC), Singapore
Conditions:
Obesity
Diabetes
Eligibility:
MALE
21-55 years
Phase:
PHASE2
Brief Summary
The primary aim of our study was to examine the effects of two weeks of oral resveratrol on resting energy expenditure and insulin sensitivity in non-diabetic obese male subjects. Secondary variables ...
Detailed Description
Patients were recruited between July 2009 and July 2012 from a single hospital in Singapore. Eligible patients were Chinese males, aged between 21 and 55 years old, with a body mass index (BMI) of 30 ...
Eligibility Criteria
Inclusion
- Ability to give informed consent
- Obese Chinese Male
- Age 21 to 55 yrs old
- No diabetes mellitus
- BMI of 30 kg/m2 or more during screening
Exclusion
- Unwilling to abstain from ingesting large quantities of resveratrol-containing foods (eg. red wine, nuts)
- Cancer diagnosis that is currently under treatment, is clinically detectable, or that has been treated within the past 5 years
- Terminal disease or on palliative care
- Current excessive alcohol intake (\>21 units per week for men; 14 units per week for women)
- Known diabetes mellitus
- Past history of unexplained hypoglycemia
- Past or current history of strokes
- History of any grape allergy
- On alternative or traditional medications
- Treated with another investigational drug within last 6 months
- Poorly controlled hypertension (SBP \>/= 160 or DBP \>/= 100) within last one month
- ALT and/or AST \> 1.5 times above upper limit of normal within last 6 months
- GFR \< 50 ml/min/1.73m2 (MDRD equation) within last 6 months
- Staff of Department of Medicine, Khoo Teck Puat Hospital
Key Trial Info
Start Date :
July 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2012
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT02247596
Start Date
July 1 2009
End Date
October 1 2012
Last Update
September 25 2014
Active Locations (1)
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1
Khoo Teck Puat Hospital
Singapore, Singapore, 768828