Status:
COMPLETED
Effect of Remote Ischemic Conditioning in Patients With Chronic Ischemic Heart Failure
Lead Sponsor:
University of Aarhus
Collaborating Sponsors:
Aarhus University Hospital Skejby
Central Jutland Regional Hospital
Conditions:
Chronic Systolic Heart Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The present study will evaluate whether treatment with daily remote ischemic conditioning for a 28±4-day period induces beneficial effects in subjects with and without chronic ischemic heart failure i...
Detailed Description
Background Chronic heart failure (CHF) is a leading cause of morbidity and mortality throughout the world, and the incidence and prevalence are increasing as more patients survive their acute coronary...
Eligibility Criteria
Inclusion
- Group 1 (Chronic heart failure patients):
- \>18 years of age
- Able to understand the written patient information and to give informed consent
- Chronic congestive ischemic heart failure
- Left ventricular ejection fraction ≤45%
- New York Heart Association functional class I-III
Exclusion
- Recent cardiovascular hospitalization (within last 30 days) • Strenuous exercise within 72 hours of either study visits
- Intake of caffeine within 24 hours of either study visit
- Intake of alcohol within 24 hours of either study visit
- Patients with permanent atrial fibrillation • Patients with diabetes mellitus
- Patients with peripheral neuropathy
- Patients in dialysis treatment
- Contraindication for Magnetic Resonance Imaging examination (e.g. metal implants including Cardiac Resynchronisation Therapy devices and other pacemakers or defibrillators) precluding Magnetic Resonance Imaging
- Other concomitant disease or treatment that according to the investigator's assessment makes the patient unsuitable for study participation.
- Group 2 (Volunteers without ischemic heart disease):
- Inclusion criteria:
- \>18 years of age
- Able to understand the written patient information and to give informed consent
- Left ventricular ejection fraction \>45%
- Exclusion criteria:
- Recent cardiovascular hospitalization (within last 30 days)
- Intake of acetylsalicylic acid or non-steroidal anti-inflammatory drug medication within 7 days of either study visit
- Strenuous exercise within 72 hours of either study visit
- Intake of caffeine within 24 hours of either study visit
- Intake of alcohol within 24 hours of either study visit
- Patients with ischemic heart disease
- Patients with diabetes mellitus
- Patients with peripheral neuropathy
- Patients in dialysis treatment
- Patients in treatment with Vitamin K-antagonists, adenosine diphosphate-receptor-inhibitor, oral anticoagulants or dipyridamol.
- Conditions contraindicating short term cessation of acetylsalicylic acid and/or non-steroidal anti-inflammatory drug intake
- Contraindication for Magnetic Resonance Imaging examination (e.g. metal implants) precluding Magnetic Resonance Imaging
- Other concomitant disease or treatment that according to the investigator's assessment makes the patient unsuitable for study participation.
Key Trial Info
Start Date :
September 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2016
Estimated Enrollment :
47 Patients enrolled
Trial Details
Trial ID
NCT02248441
Start Date
September 1 2014
End Date
February 1 2016
Last Update
August 24 2017
Active Locations (1)
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1
Aarhus University Hospital Skejby
Aarhus N, Dk-8200 Aarhus N, Denmark, 8200