Status:
COMPLETED
Intravenous Clonidine for Sedation in Infants and Children Who Are Mechanically Ventilated - Dosing Finding Study
Lead Sponsor:
Johns Hopkins University
Conditions:
Mechanical Ventilation Complication
Eligibility:
All Genders
1-12 years
Phase:
PHASE1
Brief Summary
Critically ill infants and children who are mechanically ventilated are often given large doses of opiates and benzodiazepines to provide analgesia-sedation. These drugs significantly cause tolerance ...
Detailed Description
All critically ill mechanically ventilated infants and children receive intravenous analgesic-sedatives which often include opiates and benzodiazepines (BENZO). Undesirable side effects from these dru...
Eligibility Criteria
Inclusion
- Infants and children age: 0-12 months
- Intubated and mechanically ventilated in the JHH PICU
- Meet criteria for starting dexmedetomidine (per PICU protocol)
Exclusion
- Postoperative from complex congenital heart disease
- Asphyxia
- Traumatic Brain Injury
- Major Chromosomal anomaly (Trisomy 13, 18)
- Any infant or child who is receiving ECMO therapy
- If death is considered imminent
Key Trial Info
Start Date :
September 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2019
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT02249039
Start Date
September 1 2015
End Date
December 1 2019
Last Update
March 1 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Johns Hopkins Hospital
Baltimore, Maryland, United States, 21287