Status:
TERMINATED
Evaluating Anodal tDCS Preceding Aphasia Therapy
Lead Sponsor:
Northwell Health
Conditions:
Stroke
Aphasia
Eligibility:
All Genders
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
The purpose of this study is to determine if non-invasive brain stimulation (transcranial direct current stimulation) delivered prior to language therapy will improve word-finding in individuals with ...
Eligibility Criteria
Inclusion
- ≥ 18 years of age
- First single focal unilateral left hemisphere lesion with diagnosis verified by brain imaging (MRI or CT scans) that occurred at least 6 months prior
- Pre-morbidly right handed
- Pre-morbidly fluent English speaker
- Cognitive function sufficient to understand the experiments and follow instructions (per interview with Speech Pathologist)
- A baseline Aphasia Quotient score between 10 to 94 out of 100 points on the Western Aphasia Battery (neither completely without language comprehension/expression nor fully recovered from aphasia).
Exclusion
- Ongoing use of CNS-active medications
- Ongoing use of psychoactive medications, such as stimulants, antidepressants, and anti-psychotic medications
- Presence of additional potential tDCS risk factors:
- Damaged skin at the site of stimulation (i.e., skin with ingrown hairs, acne, razor nicks, wounds that have not healed, recent scar tissue, broken skin, etc.)
- Presence of an electrically, magnetically or mechanically activated implant (including cardiac pacemaker), an intracerebral vascular clip, or any other electrically sensitive support system
- Metal in any part of the body, including metal injury to the eye (jewelry must be removed during stimulation)
- A history of medication-resistant epilepsy in the family
- Past history of seizures or unexplained spells of loss of consciousness during the previous 36 months
- Pregnancy in women, as determined by self-report
Key Trial Info
Start Date :
September 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2017
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT02249819
Start Date
September 1 2014
End Date
November 1 2017
Last Update
April 5 2021
Active Locations (1)
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1
Feinstein Institute for Medical Research
Manhasset, New York, United States, 11030