Status:
COMPLETED
New Quantitive MRI Parameters in Assessing Kidneys of Autosomal Dominant Polycystic Kidney Disease
Lead Sponsor:
Mayo Clinic
Conditions:
Autosomal Dominant Polycystic Kidney Disease
Kidney Disease
Eligibility:
All Genders
18-30 years
Brief Summary
The purpose of this study is to establish normal Magnetic Resonance quantitative values (tissues stiffness, Apparent Diffusion Coefficient values and Blood Oxygen Level Determination values for both r...
Eligibility Criteria
Inclusion
- Inclusion criteria ADPKD participants
- Male and female subjects between 18-30 years of age
- Diagnosis of ADPKD
- Glomerular Filtration Rate (GFR) of \> or = to 60 mL/min (Chronic Kidney Disease-Epidemiology Collaboration equation)
- Ability to provide written, informed consent
- Exclusion criteria for ADPKD participants
- Clinically significant concomitant systemic disease
- Subjects with Diabetes Mellitus
- Urinary protein excretion
- Abnormal urinalysis suggestive of concomitant glomerular disease
- Subjects having contraindications to, or interference with MRI assessments
- Subjects with supine blood pressure higher than 140/90 mm Hg or taking blood pressure medications
- Inclusion criteria for Normal Volunteers
- Male and female subjects between 18-30 years of age
- Glomerular Filtration Rate (GFR) of \> or = to 60 mL/min (Chronic Kidney Disease-Epidemiology Collaboration equation)
- Ability to provide written, informed consent
- Exclusion criteria for Normal Volunteers
- Previous personal or family history of kidney disease
- Clinically significant concomitant systemic disease
- Subjects with Diabetes Mellitus
- Urinary protein excretion
- Abnormal urinalysis suggestive of concomitant glomerular disease
- Subjects having contraindications to, or interference with MRI assessments
- Subjects with supine blood pressure higher than 140/90 mm Hg or taking blood pressure medications
Exclusion
Key Trial Info
Start Date :
December 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2016
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT02250287
Start Date
December 1 2014
End Date
March 1 2016
Last Update
June 17 2016
Active Locations (1)
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1
Mayo Clinic
Rochester, Minnesota, United States, 55905