Status:
COMPLETED
A Pharmacokinetic Study of Minocycline in Male and Female Volunteers
Lead Sponsor:
Vyne Therapeutics Inc.
Conditions:
Acne
Eligibility:
All Genders
18-35 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to assess the pharmakokinetic profile of Minocycline in FMX-101 4% foam product in male and female some of which are with acne
Detailed Description
This is an open-label, single-center, non-randomized, multiple-administrations study in males and females, some of which are with acne. Twelve (12) subjects will be enrolled to receive a daily dose o...
Eligibility Criteria
Inclusion
- Men and women between 18 and 35 years (inclusive) of age.
- Clear skin or facial acne of any severity, currently untreated
- Otherwise healthy subjects
- Subjects who provide written informed consent to participate in the study.
- Women of childbearing potential who are willing to use 2 reliable methods of contraception or practice abstinence during the study period or be surgically sterilized and agree to undergo repeated pregnancy tests.
- Body Mass Index (BMI) 19.0 to \<30.0 kg/m2 and weight ranging between 60-90 kg (males) and 50-85 (females).
- Non-smoking and no use of any tobacco or nicotine products (by declaration) for a period of at least 6 months prior to screening visit
- Subjects in general good health in the opinion of the investigator as determined by medical history, vital signs, ECG and a physical examination.
- Shaven facial hair (males)
- Negative HIV, Hepatitis B and Hepatitis C serology tests at screening.
- No clinically significant abnormalities in hematology, blood chemistry, or urinalysis lab tests at screening.
- No known history of alcohol or drug abuse. Negative urinary screen for drugs of abuse determined within 21 days of the start of the study (screening visit).
- Willingness to minimize exposure to sun for 20 days after first dosing
- Subjects must be able to understand the requirements of the study and must be willing to comply with the requirements of the study
Exclusion
- Documented history or ongoing symptoms of significant neurological, renal, cardiovascular, respiratory (asthma), endocrinological, gastrointestinal, hematopoietic disease, neoplasm or any other clinically significant medical disorder, which in the investigator's judgment contraindicate administration of the study medications.
- Known or suspected pregnancy or lactation or planned pregnancy during the study duration (females)
- Use of topical antibiotics or topical corticosteroids for acne treatment within the past 2 weeks.
- Use of systemic corticosteroids within the past 4 weeks.
- Use of systemic retinoids (e.g. isotretinoin) within the past 6 months.
- Concurrent use of medications known to be photosensitizers because of the possibility of augmented photosensitivity.
- History or evidence of skin conditions other than acne (eg, eczema) that would interfere with the subject's participation in the study.
- Use of any prescription or over-the-counter (OTC) medications, vitamins and herbal or dietary supplements within 14 days prior to dosing. Paracetamol or ibuprofen for symptomatic relief of pain is allowed until 24 hours prior to the study drug administration.
- Dermatological conditions which might have an effect upon dermal application, e.g.: Psoriasis, mycosis fungoides, widespread acne, facial or back dermatophytosis, severe hyperhydrosis, chronic or recurrent skin infections, ichtyosis
- Excessive hair in the intended application areas
- Current or recent (within 1year) drug or alcohol abuse.
- Known contraindication, hypersensitivity and/or allergy to the study drug or its excipients.
- Subjects with significant allergic response to other drugs
- Any acute illness (e.g. acute infection) within 48 hours prior to the first study drug administration, which is considered of significance by the Principal Investigator.
- Participation in another clinical trial with drugs received within 3 months prior to dosing (calculated from the previous study's last dosing date).
- Subjects who donated blood in the three months or received blood or plasma derivatives in the six months preceding study drug administration.
- Subjects unable to communicate well with the investigators and CRC staff (i.e., language problem, poor mental development or impaired cerebral function).
- Subjects who are non-cooperative or unwilling to sign consent form.
Key Trial Info
Start Date :
September 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2015
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT02250859
Start Date
September 1 2014
End Date
January 1 2015
Last Update
February 25 2021
Active Locations (1)
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1
Sourasky Medical Center, Clinical Research Center
Tel Aviv, Israel