Status:
UNKNOWN
The Influence of Glycaemia and Insulinemia on Vasomotor Endothelial Function After Myocardial Infarction
Lead Sponsor:
University of Campinas, Brazil
Conditions:
Myocardial Infarction
Eligibility:
All Genders
40-70 years
Brief Summary
The objective of this study is to investigative the influence of different levels of glycaemia or insulinemia in vascular endothelium in ischemia/reperfusion lesion after myocardial infarction
Detailed Description
The study will include patients consecutively admitted with acute myocardial infarction at State University of Campinas Hospital. Participants will be evaluated during hospitalization and, after they ...
Eligibility Criteria
Inclusion
- less than 12 hours from the onset of symptoms of STEMI,
- reperfusion therapy performed less than 6 hours of symptom onset.
Exclusion
- patients that after 24 hours did not show markers of myocardial necrosis
- diabetes or use of oral antidiabetics
- admission with glycosylated hemoglobin ≥ 6.5%
- patients with creatinine clearance \<50 ml / min,
- patients with BMI ≥ 40 kg / m2,
- premenopausal women,
- patients that used nitrate or vasoactive drugs (norepinephrine, dobutamine, nitroglycerin or nitroprussiate in 48h prior to the examination of endothelial function
- cardiac dysfunction in acute MI with or without repercussion clinic, diagnosed by ejection fraction less than 50% left ventricle.
- FMD values above or below 2 standard deviations or more from the average of these tests
Key Trial Info
Start Date :
July 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 1 2016
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT02250989
Start Date
July 1 2014
End Date
February 1 2016
Last Update
September 26 2014
Active Locations (1)
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1
Clinics Hospital
Campinas, São Paulo, Brazil, 13083-888