Status:
COMPLETED
Pharmacokinetics of Glucocorticoids in Children (GLUCOPED)
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Collaborating Sponsors:
URC-CIC Paris Descartes Necker Cochin
Conditions:
Children Receiving Prednisone or Prednisolone or Methylprednisolone or Hydrocortisone
Eligibility:
All Genders
Brief Summary
The purpose of this study is to determine individual susceptibility factors (drug interactions, genetic factors such as enzyme polymorphism…) to explain wide interindividual variability towards cortic...
Detailed Description
Corticosteroids are widely used in children. A large interindividual variability exists concerning both efficacity and tolerance. Pharmacokinetic is poorly known. A knowledge of individual susceptibi...
Eligibility Criteria
Inclusion
- receiving Prednisone or Prednisolone or Methylprednisolone or hydrocortisone
- recruited in Immuno-hematological unit, dermatological unit, in pediatric nephrological unit, pediatric intensive care unit, or pediatric neurology unit
- parental agreement
Exclusion
- parental refusal
- inability to take a blood sample
- inhaled corticoids intake in the 3 previous days
- topical corticoids intake in the 3 previous days
Key Trial Info
Start Date :
December 3 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 9 2021
Estimated Enrollment :
146 Patients enrolled
Trial Details
Trial ID
NCT02252237
Start Date
December 3 2014
End Date
December 9 2021
Last Update
November 20 2025
Active Locations (1)
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1
AP-HP Necker
Paris, France, 75015