Status:
COMPLETED
Exercise in Air Pollution and Lung Health in Asthmatics
Lead Sponsor:
University of British Columbia
Collaborating Sponsors:
Canadian Academy of Sport and Exercise Medicine (CASEM)
Natural Sciences and Engineering Research Council, Canada
Conditions:
Exercise-induced Bronchoconstriction
Air Pollution
Eligibility:
All Genders
19-40 years
Phase:
NA
Brief Summary
When exposed to air pollution, the asthma symptoms are aggravated and lung function is impaired. Due to high breathing rates and volumes, physically active individuals are at particular risk of lung h...
Eligibility Criteria
Inclusion
- mild-moderate asthmatics with controlled treatment (definition of "mild": percent fall index at eucapnic voluntary hyperpnea (EVH) test on screening day between 10-15%; "moderate": percent fall index at EVH test on screening day between 15 - 20%).
- men and non-pregnant women
Exclusion
- any history of uncontrolled respiratory or cardiac disease
- pregnancy
- allergic reactions to lidocaine and salbutamol
- any recent infections or orthopaedic nasal issues/injuries that may interfere with the insertion of the catheter needed to assess expiratory flow limitation or work of breathing
- claustrophobia in small rooms, comparable to the air pollution chamber used for this study.
- English as a second language (ESL) - participants who are not able to understand the risk that may be associated with the participation in this study due to language difficulties after following the University of British Clinical Research Ethics Board Guidance Notes 13.2.1. (ESL participants will be given a consent form in the most appropriate language or an appropriate translator will be present during the initial consent process).
Key Trial Info
Start Date :
May 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2021
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT02252302
Start Date
May 1 2015
End Date
May 1 2021
Last Update
September 30 2021
Active Locations (1)
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1
University of British Columbia, Environmental Physiology Laboratory
Vancouver, British Columbia, Canada, V6T 1Z1