Status:
UNKNOWN
The Effect of Phenylephrine and Ephedrine on Microvascular Blood Flow
Lead Sponsor:
University of Nottingham
Conditions:
Healthy Volunteers
Eligibility:
MALE
18-60 years
Brief Summary
During operations to treat abdominal problems the blood pressure can fall, resulting in falls in blood flow to the vital organs. This fall can be treated by the administration of drugs that cause cons...
Detailed Description
Optimising the cardiac output is essential to ensure adequate organ perfusion in patients who are undergoing major surgery. To enable this cardiac output (CO) is frequently monitored during operations...
Eligibility Criteria
Inclusion
- Aged 18-60 years
- Male
- Able to consent in English by themselves
- Absence of any exclusion criteria
Exclusion
- A BMI \< 20 or \> 28 kg•m2
- Active cardiovascular disease: uncontrolled hypertension (BP \> 140/90), angina, heart failure (class III/IV), arthymia, right to left cardiac shunt or recent cardiac event
- Individuals taking alpha or beta-adrenergic blocking agents, monoamine oxidase inhibitors, tricyclic antidepressants, serotonin or noradrenaline selective reuptake inhibitors, quinidine, cardiac glycosides or buspirone (or who have ceased taking them in the previous 14 days¬)
- Cerebrovascular disease: previous stroke, aneurysm (large vessel or intracranial)
- Peripheral vascular disease
- Metabolic disease: hyper and hypo parathyroidism, untreated hyper and hypothyroidism, Cushing's disease, types 1 or 2 diabetes
- Active inflammatory bowel disease, or renal disease
- Known prostatic hypertrophy
- Malignancy
- Clotting dysfunction
- Previous oesophageal surgery
- Individuals with a known history of oesophageal varices
- Individuals with a known history of epistaxis
- Family history of early (\<55y) death from cardiovascular disease
- Known sensitivity to SonoVue, ephedrine or phenylephrine
- Participants who have taken part in any other research study in the last three months which involved: taking a drug; being paid a disturbance allowance; having an invasive procedure (eg blood sample \>50ml, muscle biopsies) or exposure to ionising radiation.
Key Trial Info
Start Date :
August 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2015
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT02252627
Start Date
August 1 2014
End Date
August 1 2015
Last Update
January 27 2015
Active Locations (1)
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1
University of Nottingham, School of Medicine, Division of Medical Sciences and Graduate Entry Medicine
Derby, Derbyshire, United Kingdom, DE22 3DT