Status:
COMPLETED
Self Focus in Bipolar Disorder: A Functional Magnetic Resonance Imaging (fMRI) Study
Lead Sponsor:
Massachusetts General Hospital
Collaborating Sponsors:
Brain & Behavior Research Foundation
Conditions:
Bipolar Disorder
Major Depression
Eligibility:
All Genders
18-64 years
Brief Summary
The investigators propose to examine both resting state activity and functional activity during rumination and during self-processing to study the relationship between neural correlates of rumination/...
Detailed Description
Negative rumination, a specific form of self-focus, characterized by repetitively focusing on one's symptoms of distress, and the possible causes and consequences of these symptoms, is a hallmark of d...
Eligibility Criteria
Inclusion
- Inclusion Criteria Healthy Controls:
- Right-handed (as determined by the Handedness Inventory; Oldfield, 1971)
- Normal or corrected-to normal vision and hearing
- Exclusion Criteria for Healthy Controls:
- Any current or past psychiatric history
- Significant medical, psychiatric or neurological illness
- Currently taking antidepressants, mood stabilizers, or benzodiazepines
- Positive MR screen (e.g., metal implant, claustrophobia, etc)
- Inclusion Criteria for Patients with Major Depression:
- Current diagnosis of MDD
- Right-handed (as determined by the Handedness Inventory; Oldfield, 1971)
- Normal or corrected-to normal vision and hearing
- Exclusion Criteria for MDD Patients:
- If a history of substance abuse, at least 6 months in remission
- Current suicidal ideation or history of suicide attempts
- Positive MR screen (e.g., metal implant, claustrophobia, etc)
- Inclusion Criteria for patients with BPAD:
- Current diagnosis of BPAD
- Right-handed (as determined by the Handedness Inventory; Oldfield, 1971)
- Normal or corrected-to normal vision and hearing
- Exclusion Criteria for BPAD Patients:
- If a history of substance abuse, at least 6 months in remission
- Current suicidal ideation or history of suicide attempts
- Positive MR screen (e.g., metal implant, claustrophobia, etc)
Exclusion
Key Trial Info
Start Date :
January 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2020
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT02253225
Start Date
January 1 2013
End Date
January 1 2020
Last Update
September 1 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114