Status:
COMPLETED
Innovative MRI Techniques to Improve Treatment Stratification of Patients With Esophageal Cancer
Lead Sponsor:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Conditions:
Esophageal Neoplasms
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The current standard treatment of resectable esophageal cancer consists of neoadjuvant chemoradiation followed by resection. However, some patients develop recurrent disease despite chemoradiation and...
Detailed Description
The outcome of esophageal cancer is poor, with an overall 5-year survival rate of 10% worldwide. In resectable esophageal cancer, outcome can be improved by multimodality treatment. The current standa...
Eligibility Criteria
Inclusion
- Patients with biopsy proven esophageal cancer (squamous cell carcinoma or adenocarcinoma)
- Suspected nodal involvement on EUS or CT at diagnosis.
- WHO-performance score 0-2
- Scheduled for surgery
- Written informed consent
Exclusion
- Any psychological, familial, sociological or geographical condition potentially hampering adequate informed consent or compliance with the study protocol
- Contra-indications for MR scanning, including patients with a pacemaker, cochlear implant or neurostimulator; patients with non-MR compatible metallic implants in their eye, spine, thorax or abdomen; or a non-MR compatible aneurysm clip in their brain; patients with severe claustrophobia
- Active inflammatory diseases
- History of anaphylaxis or other hypersensitivity reactions
- History of iron overload
- History of abnormal liver function, or elevated liver enzymes (ALAT, ASAT \> 3 times upper limit of normal)
- Elevated Serum Transferrin Saturation (TSAT) (\>50%) or hemoglobin (\>10.5mmol/L)
Key Trial Info
Start Date :
September 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2018
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT02253602
Start Date
September 1 2014
End Date
May 1 2018
Last Update
January 16 2019
Active Locations (1)
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1
Academic Medical Center
Amsterdam, North Holland, Netherlands, 1105AZ