Status:
WITHDRAWN
Palliative Use of High-flow Oxygen Nasal Cannula in End-of-life Lung Disease Patients
Lead Sponsor:
Hospital Sao Joao
Conditions:
Lung Disease
Acute Respiratory Distress Syndrome
Eligibility:
All Genders
21+ years
Phase:
NA
Brief Summary
The prevalence of severe dyspnoea among terminally ill patients has been reported as 70% and 90% for lung cancer and chronic obstructive pulmonary disease (COPD) patients, respectively. Current manag...
Eligibility Criteria
Inclusion
- Consecutive patients who had end-stage lung disease (lung cancer, pulmonary fibrosis, COPD, …) - (McCabe score \> 3 \[\<6 months life expectancy\] and a Palliative Prognostic Index score ≥ 4) admitted to hospital because of acute respiratory failure and distress
- Had chosen to forego all life support and receiving only palliative care
- Severe hypoxemia (PaO2/FiO2\< 250)
- At least one of the following: dyspnoea (Borg scale ≥4), signs of respiratory distress, and respiratory rate greater than 30 beats per min
Exclusion
- Patients had to be competent (Kelly score \<4)
- Refusal of treatment
- Weak cough reflex
- Agitation or non-cooperation
- Uncontrolled cardiac ischemia or arrhythmias
- Failure of more than two organs
- Use of opioids within the past 2 weeks
- Adverse reactions to opioids
- History of substance misuse
- Known contraindication for morphine (acute renal failure and recent head injury)
Key Trial Info
Start Date :
September 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2015
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT02253667
Start Date
September 1 2014
End Date
September 1 2015
Last Update
January 25 2017
Active Locations (1)
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1
University Hospital of São João
Porto, Porto District, Portugal, 4200-319