Status:
COMPLETED
Telmisartan and Hydrochlorothiazide Antihypertensive Treatment Study in High Sodium Intake Population
Lead Sponsor:
The George Institute for Global Health, China
Collaborating Sponsors:
Peking University People's Hospital
Conditions:
Hypertension
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
In this research, the investigators aim to compare the antihypertensive efficacy and safety of monotherapy of routine dose angiotensin receptor antagonist telmisartan (ARB) and diuretic Hydrochlorothi...
Eligibility Criteria
Inclusion
- Age≥18
- Essential hypertension: systolic blood pressure (SBP) is between 140mmHg-179mmHg and diastolic blood pressure (DBP)\<110mmHg OR DBP is between 90mmHg-109mmHg and SBP\<180mmHg.
- Hypertension patients diagnosed by spot urine test (urine sodium≥200mmol/24h).
- Subjects are not using antihypertensive medicines or medicines which affect the blood pressure within a week.
- Subjects volunteer to be brought in the research and have signed informed consent form, given that they have understood the research content.
Exclusion
- Females who are already pregnant, in lactation and intend to be pregnant.
- Patients who have seriously allergic reaction or angioneurotic edema when taking ARB; Patients who have allergic history of thiazide diuretic (HCTZ) or sulfonamides.
- Patients who do not want to stop or have to take the medicines which are also antihypertensive or affect the blood pressure, other than which provided by the research.
- Stroke or CHD patients who are diagnosed within 6 months. CHD patients are identified by being diagnosed by coronary arteriography or coronary CT angiography, having received coronary stent or coronary artery bypass surgery, or being diagnosed with acute myocardial infarction. Stroke patients are identified by being diagnosed with cerebral thrombosis, cerebral embolism, cerebral hemorrhage, subarachnoid hemorrhage or transient ischemic attack.
- Patients who are clearly diagnosed with following diseases: Congenital disease, myocardiopathy, serious arrhythmia, pulmonary heart disease, various of cardiac failure.
- Patients who are clearly diagnosed with following symptoms or diseases: Proteinuria or heavy proteinuria, renal insufficiency or serious renal function damage, hepatic insufficiency or serious hepatic function damage; retinal exudates or hemorrhage, or papilledema.
- Patients who are clearly diagnosed with serious or deadly diseases in other systems.
- Patients who get dementia or other serious diseases cannot cooperate with researchers.
- Patients who drink 200g white spirits per day in past week.
- Patients who meet other situations which are considered to be inappropriate to be enrolled into the study by researchers.
Key Trial Info
Start Date :
October 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2015
Estimated Enrollment :
1410 Patients enrolled
Trial Details
Trial ID
NCT02255253
Start Date
October 1 2014
End Date
March 1 2015
Last Update
March 11 2015
Active Locations (14)
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1
Chinese Traditional Medicine Hospital of Anguo
Baoding, Hebei, China, 071200
2
Boye hospital
Baoding, Hebei, China, 071300
3
Lixian chinese traditional medicine hospital
Baoding, Hebei, China, 071400
4
Gaoyang hospital
Baoding, Hebei, China, 071500