Status:

COMPLETED

NIV Strategies for RDS in Preterm Infants. NIV (Non Invasive Ventilation), RDS (Respiratory Distress Syndrome)

Lead Sponsor:

Azienda Ospedaliera Universitaria Policlinico "G. Martino"

Collaborating Sponsors:

Vittore Buzzi Children's Hospital

Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria

Conditions:

RDS of Prematurity

Eligibility:

All Genders

Up to 2 years

Phase:

PHASE2

PHASE3

Brief Summary

The purpose of this study is to determine whether two different strategies of Non Invasive Ventilation (NIV) have different effect on length and failure of NIV support in preterm infants with respirat...

Detailed Description

A Randomized Control Trial (RCT) conducted in two tertiary level Neonatal Intensive Care Unit (NICU). Ethical approval is needed. Informed and written consent will be obtained prior the delivery from ...

Eligibility Criteria

Inclusion

  • All inborn VLBW infants (birthweight less than 1500 g and Gestational Age \< 32 wks) with signs of RDS, spontaneously breathing and only supported by N-CPAP, will be randomized within the first 2 hours of life to receive two different Non Invasive Ventilation (NIV) strategies.

Exclusion

  • Apneic or severely depressed newborns requiring invasive ventilation, within two hours from birth
  • Newborns with genetic disease and/or with major congenital malformations
  • Newborns for whom it was not obtained informed consent within two hours from birth

Key Trial Info

Start Date :

January 1 2010

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

December 1 2012

Estimated Enrollment :

280 Patients enrolled

Trial Details

Trial ID

NCT02259400

Start Date

January 1 2010

End Date

December 1 2012

Last Update

February 18 2015

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