Status:
COMPLETED
Multi-modality MRI Study on Effect to Collateral Circulation and Blood Perfusion of Acute Cerebral Infarction by Human Urinary Kallidinogenase
Lead Sponsor:
XuanwuH 2
Conditions:
Cerebral Infarction
Eligibility:
All Genders
18-70 years
Phase:
PHASE2
Brief Summary
Human urinary kallidinogenase can promote the establishment of collateral circulation in the ischemic penumbra due to the stenosis or occlusion of middle cerebral artery and then increase the perfusio...
Detailed Description
Patients with acute ischemic stroke will be given human urinary kallidinogenase .Then we will estimate the cerebral collateral circulation in ischemic regions and final infarct volume, comparing with ...
Eligibility Criteria
Inclusion
- Age:greater than or equal to 18 years old and less than or equal to 70 years old;
- Time of onset is less than 7 days;
- Acute cerebral infarction due to the stenosis or occlusion of middle cerebral artery diagnosed by CT or MRI;
- The National Institute of Health Stroke Scale(NIHSS) score is 4 to 20;
- Excluding intracranial hemorrhage using CT or MRI.
Exclusion
- The NIHSS score is less than or equal to 3;
- Patients with cerebral aneurysm, cerebral hemorrhage, brain tumor, brain contusion and laceration of brain and other diseases;
- Intracranial hemorrhage displaying by CT or MRI; Cardiac insufficiency;
- Cardiac insufficiency;
- Chronic liver disease(A/G inversion),elevated alanine aminotransferase(ALT)(more than 1.5 times the normal value);
- Increased serum creatinine(more than 1.5 times the normal value);
- Poorly controlled diabetes;
- Recently suffered from hemorrhagic disease or bleeding tendency;
- Recent use of angiotensin-converting enzyme inhibitor (ACEI) drugs;
- Allergic constitution and had a variety of drug allergy history;
- Women in period of pregnancy or lactation.
Key Trial Info
Start Date :
January 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2014
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT02259738
Start Date
January 1 2013
End Date
June 1 2014
Last Update
October 8 2014
Active Locations (1)
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1
Department of Neurolgy,Xuanwu Hospital of Capital Medical University
Beijing, Beijing Municipality, China, 100053