Status:
COMPLETED
Examination of the Pathophysiologic Mechanisms of CRPS by Using QST, CPM, RIC, and Heart Rate Variability QST
Lead Sponsor:
Ruhr University of Bochum
Conditions:
Complex Regional Pain Syndrome
Carpal Tunnel Syndrome
Eligibility:
All Genders
18+ years
Brief Summary
This study aims for a better understanding of the pathophysiological mechanisms of the complex regional pain syndrome (CRPS). This will be done by testing the quantitative sensory testing, the remote ...
Detailed Description
CRPS is an illness which (seriously) affects patients in their daily life activity. The fact that the pathophysiological mechanisms are not well understood yet makes it hard to treat these patients in...
Eligibility Criteria
Inclusion
- CRPS-patients
- Inclusion Criteria:
- Unilateral pain on the upper limbs, based on a scintigraphic ensured CRPS (average pain in the last 4 weeks ≥ 3 in pain Detect)
- Pain history \< 1 year
- Exclusion criteria:
- Bilateral pain on the upper limbs
- Inadequate knowledge of the german language in speaking and writing
- Acute psychiatric sickness
- Polyneuropathy
- Any added neuropathic sickness on the not affected upper limb sight
- Intolerable pain during the testing
- Injuries within the tested areal
- Acute injuries on the hand
- Pregnancy
- Missing informed consent
- CTS-patients
- Inclusion Criteria:
- Unilateral pain on the upper limbs, based on a scintigraphic ensured CRPS (average pain in the last 4 weeks ≥ 3 in pain Detect)
- Pain history \< 1 year
- Exclusion criteria:
- Bilateral pain on the upper limbs
- Inadequate knowledge of the german language in speaking and writing
- Acute psychiatric sickness
- Polyneuropathy
- Any added neuropathic sickness on the not affected upper limb sight
- Intolerable pain during the testing
- Injuries within the tested areal
- Acute injuries on the hand
- Pregnancy
- Missing informed consent
- Healthy subjects
- Inclusion Criteria:
- Age \> 18 years
- Written consent
- Exclusion criteria:
- Inadequate knowledge of the german language in speaking and writing
- Current pain
- Pain within in the last 14 days
- Any serious internistic medicin
- Any chronic skin disease
- Any central neural sickness
- Polyneuropathy
- Peripheral nerve lesion within the testing areal
- Any radiculopathy with permanent pain (in the last 3 months)
- Any psychiatric sickness
- Migraine ( at least one attack in the last 24 h)
- Repeating headache (in the last 3 month on \>5 days/month)
- Taking any analgesics in the last 14 days
- Taking triptans in the last 24 months
- Taking any psychotropic's in the last 3 months
- Any repeated taking of medication, including amber or different psychostimulants (excluding contraceptives)
- Taking of any prescription and non-prescription drugs (except contraceptives) in the last 7 days or 5 half-life periods(which is always longer) before including into the study
- Achilles reflex absent or within in the side-difference pathologic hypoactive or hyperactive
- pallaesthesia \<5/8 (\<4/8 at \>60 years) on the internal malleolus on both sides
- abuse of alcohol or medications/drugs (corresponding to the DSM IV criteria)
- joining a medical study \<30 days before inclusion into the current study
- jet lag, irregular work schedule, sleep deprivation within the last 3 days
- change of intestity during physical activity, e.g. beginning an activity in the last weeks before inclusion into the current study
Exclusion
Key Trial Info
Start Date :
April 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2015
Estimated Enrollment :
62 Patients enrolled
Trial Details
Trial ID
NCT02261012
Start Date
April 1 2014
End Date
August 1 2015
Last Update
February 9 2016
Active Locations (1)
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1
Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil GmbH
Bochum, North Rhine-Westphalia, Germany, 44789