Status:
COMPLETED
Day-Night Rhythm in Human Skeletal Muscle
Lead Sponsor:
Maastricht University Medical Center
Conditions:
Diabetes Mellitus, Type 2
Insulin Resistance
Eligibility:
MALE
18-35 years
Phase:
NA
Brief Summary
This study evaluates the existence of a day-night rhythm in skeletal muscle energy metabolism in healthy lean subjects. Subjects will stay at the research facility for 44 hours with a standardized liv...
Detailed Description
Recent evidence from both observational and experimental studies indicates that disobeying our normal day-night rhythm negatively influences our metabolic and cardiovascular health, possibly leading t...
Eligibility Criteria
Inclusion
- Caucasian
- Healthy (as determined by dependent physician based on medical questionnaire)
- Male
- Age: 18-35 years
- Normal BMI (18-25 kg/m2)
- Regular sleeping time (normally 7-9h daily)
Exclusion
- Extreme early bird or extreme night person (score ≤30 or ≥70 on MEQ-SA questionnaire)
- Heavily varying sleep-wake rhythm
- Shiftwork during last 3 months
- Travel across \>1 time zone in the last 3 months
- Engagement in exercise \> 2 hours total per week
- Using \>400mg caffeine daily
- Smoking
- Unstable body weight (weight gain or loss \> 3kg in the last 3 months)
- Significant food allergies/intolerance (seriously hampering study meals)
- Participation in another biomedical study within 1 month before the first study visit
- Any contra-indication to Magnetic Resonance Imaging (MRI) scanning
Key Trial Info
Start Date :
November 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2015
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT02261168
Start Date
November 1 2014
End Date
July 1 2015
Last Update
September 7 2015
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Maastricht University
Maastricht, Netherlands