Status:
COMPLETED
A New Reagent Assay Examining Natural Parvovirus B19 Infection in Sickle Cell Disease
Lead Sponsor:
St. Jude Children's Research Hospital
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Sickle Cell Disease
Eligibility:
All Genders
1+ years
Brief Summary
Parvovirus B19 is a small virus that is the cause of "fifth" disease, a common infection in childhood. In people with sickle cell disease (SCD), parvovirus B19 infection causes the bone marrow to stop...
Detailed Description
Participants with sickle cell disease (SCD) will be divided into three study groups depending on their history of parvovirus B19 infection. Each will have blood drawn and/or nasopharyngeal wash which ...
Eligibility Criteria
Inclusion
- Inclusion Criteria - Individuals not experiencing an acute illness (Group A):
- Males and females with a diagnosis of SCD of any genotype
- Ages \> 1 year.
- Medical records available for verification of prior parvovirus B19 infection status.
- Exclusion Criteria - Individuals not experiencing an acute illness (Group A):
- Patients on chronic transfusion therapy.
- Patients experiencing an acute febrile illness.
- Any medical or social reason, which in the opinion of the principal investigators (PIs) would make the participation of the subject ill-advised.
- Inclusion Criteria - Individuals with confirmed (Group B) or suspected (Group C) acute parvovirus B19 infection:
- Males and females with a diagnosis of SCD of any genotype.
- Ages \> 1 year.
- Symptoms of acute parvovirus infection (defined as worsened anemia with insufficient compensatory reticulocytosis in the setting of a febrile illness).
- Exclusion Criteria - Individuals with confirmed (Group B) or suspected (Group C) acute parvovirus B19 infection:
- Patients on chronic transfusion therapy.
- Current epistaxis
- Any medical or social reason, which in the opinion of the principal investigators (PIs) would make the participation of the subject ill-advised.
Exclusion
Key Trial Info
Start Date :
October 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2016
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT02261480
Start Date
October 1 2014
End Date
August 1 2016
Last Update
September 19 2016
Active Locations (1)
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1
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105