Status:
COMPLETED
Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness: A Pilot RCT
Lead Sponsor:
Sunnybrook Health Sciences Centre
Collaborating Sponsors:
Kingston Health Sciences Centre
Conditions:
Bacteremia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Bacteremia is a leading cause of mortality and morbidity in critically ill adults. Although bacteria in the bloodstream (bacteremia) may arise from variable infectious foci (most commonly central vasc...
Eligibility Criteria
Inclusion
- Patient is in the ICU at time the blood culture result reported as positive AND
- Patient has a positive blood culture with pathogenic bacteria.
Exclusion
- Patient already enrolled in the trial
- Patient has severe immune system compromise, as defined by: absolute neutrophil count \<0.5x109/L; or is receiving immunosuppressive treatment for solid organ or bone marrow or stem cell transplant
- Patient has syndrome with well-defined requirement for prolonged treatment:
- infective endocarditis
- osteomyelitis/septic arthritis
- undrainable/undrained abscess
- unremovable/unremoved prosthetic-associated infection
- Patient has a single positive blood culture with a common contaminant organism according to Clinical Laboratory \& Standards Institute (CLSI) Guidelines: coagulase negative staphylococci; or Bacillus spp.; or Corynebacterium spp.; or Propionobacterium spp.; or Aerococcus spp.; or Micrococcus spp.
- Patient has a positive blood culture with Staphylococcus aureus.
- Patient has a positive blood culture with Candida spp. or other fungal species.
Key Trial Info
Start Date :
October 16 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 5 2017
Estimated Enrollment :
115 Patients enrolled
Trial Details
Trial ID
NCT02261506
Start Date
October 16 2014
End Date
October 5 2017
Last Update
December 18 2017
Active Locations (17)
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1
Foothills Hospital
Calgary, Alberta, Canada
2
University of Alberta Hospital
Edmonton, Alberta, Canada
3
Royal Columbian Hospital
Vancouver, British Columbia, Canada
4
St. Paul's Hospital
Vancouver, British Columbia, Canada