Status:
COMPLETED
Reduction in MACbar of Sevoflurane by Dexmedetomidine in Children
Lead Sponsor:
Cai Li
Conditions:
Children
Eligibility:
All Genders
2-6 years
Phase:
NA
Brief Summary
The study was designed to define the interaction of intravenous infusion of dexmedetomidine, an a2-adrenergic agonist, and sevoflurane in children having surgery by using the minimum alveolar concentr...
Detailed Description
The investigators observed the effects of different doses of dexmedetomidine on the minimum alveolar concentration of sevoflurane to blockade adrenergic response to surgical incision in 50% of childre...
Eligibility Criteria
Inclusion
- aged 2 to 6 yr
- American Society of anesthesiologists I or II
- scheduled to have general anesthesia and to have skin incisions on the abdomen
Exclusion
- anemia or abnormal preoperative electrolyte concentrations
- a history of cardiovascular or central nervous system diseases
- a history of pulmonary disease
- known hepatic or renal disease
- a body weight exceeding 50% of the upper limit of ideal body weight for height
- taking drugs with cardiovascular or central nervous system effects
- use of any experimental drug within the past 30 days
- allergy to any drug that may be administered during the study
- exposure to general anesthesia within the previous 7 days
- second- or third-degree atrioventricular block
- taking drugs preoperatively that would interfere with MAC determination(e.g.,opioids or sedatives)
Key Trial Info
Start Date :
January 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2014
Estimated Enrollment :
63 Patients enrolled
Trial Details
Trial ID
NCT02261675
Start Date
January 1 2013
End Date
April 1 2014
Last Update
October 10 2014
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