Status:
COMPLETED
Novel Biomarkers for Risk Prediction of Contrast-Induced Acute Kidney Injury Post Coronary Angiography
Lead Sponsor:
Sapere Bio
Collaborating Sponsors:
University of North Carolina, Chapel Hill
Conditions:
Acute Kidney Injury
Renal Insufficiency
Eligibility:
All Genders
18+ years
Brief Summary
Contrast-induced acute kidney injury (CI-AKI) has been recognized as the third most common cause of hospital acquired AKI, after hypotension-associated hypo-perfusion and post-operative AKI. The devel...
Eligibility Criteria
Inclusion
- Adult patients (\>18 yo) undergoing invasive coronary angiography with or without percutaneous coronary intervention (PCI), that are predicted to have ≥14% risk of developing AKI as defined by Mehran et al.
- Medically compliant and able to consent and follow detailed directions
- Agree to additional collection of blood sample 48-72h post cardiac catheterization
Exclusion
- Presence of acute, active infection (e.g. HIV, pneumonia, septic shock).
- Contrast media exposure within last 48h
- Presenting with systolic time-segment elevation myocardial infarction.
- Presence of cardiogenic shock
- Presence of hemodynamic instability or requiring pressors or intra-aortic balloon pump
- Severe kidney disease with estimated glomerular filtration rate \<30 mL/min/1.73m2 or receiving dialysis for end stage renal disease
- Kidney transplant and liver transplant patients and all patients currently on immunosuppressants
- Severe heart failure with known ejection fraction \<25%
- Prior heart transplant
- Chronic liver disease /cirrhosis
- Patients actively undergoing chemotherapy or radiation treatment for any indication.
Key Trial Info
Start Date :
January 1 2015
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2016
Estimated Enrollment :
185 Patients enrolled
Trial Details
Trial ID
NCT02263820
Start Date
January 1 2015
End Date
December 1 2016
Last Update
August 17 2018
Active Locations (1)
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1
UNC Center for Heart & Vascular Care
Chapel Hill, North Carolina, United States, 27599