Status:
UNKNOWN
Exercise Intensity and Immune Function in Multiple Sclerosis
Lead Sponsor:
University of the West of Scotland
Collaborating Sponsors:
National Heatlh Service Ayrshire and Arran
Conditions:
Multiple Sclerosis
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
This study aims to determine the effect of exercise intensity within a 15 week programme in moderately disabled people with multiple sclerosis (MS). Although earlier research has shown that exercise i...
Detailed Description
Recruited patients will initially undergo baseline measurements including BMI. Neurotrophin (BDNF and NGF) and cytokine (IFN-Y and IL-4) concentration will be measured from participant serum using com...
Eligibility Criteria
Inclusion
- Clinically confirmed MS (according to the revised 2010 McDonald criteria) (Polman et al., 2011)
- Expanded disability status scale (EDSS) 3.0-5.0
Exclusion
- Unable to consent due cognitive impairment or mental illness
- Immunomodulatory therapy in past 3 months
- Steroid therapy in the past 6 weeks
- Existence of medical contraindications for exercise i.e. cardiovascular or orthopaedic disease.
- Compounding neurological condition other than MS
Key Trial Info
Start Date :
November 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2015
Estimated Enrollment :
63 Patients enrolled
Trial Details
Trial ID
NCT02264704
Start Date
November 1 2014
End Date
July 1 2015
Last Update
October 15 2014
Active Locations (1)
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1
Douglas Grant Rehabilitation Centre, Ayrshire Central Hospital
Irvine, Ayrshire, United Kingdom, KA12 8SS