Status:
COMPLETED
Thalamic LFPs and VIM DBS in Essential Tremor: Correlation, Evolution, and Therapeutic Perspectives
Lead Sponsor:
University Hospital, Bordeaux
Collaborating Sponsors:
APTES 100 rue boileau 69006 Lyon
Conditions:
Essential Tremor
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
The objective of this study is to characterize through spectral analysis intra-thalamic local field potentials (LFPs) recorded through implanted DBS leads during periods with and without tremor in pat...
Detailed Description
Essential tremor (ET) is one of the most common adult movement disorders with a prevalence of 4% in the general population. Although several medications (primidone, beta-adrenergic blockers, benzodiaz...
Eligibility Criteria
Inclusion
- Patients suffering from severe and disabling ET with serious impact on their quality of life (QoL).
- 18-70 years old
- Free of evolutive and untreated psychiatric disorder
- Tremor must be predominant in the upper limbs although it can affect the lower limbs, head and voice.
- Affiliation to a social security system
- Written informed consent signed by the participant and the investigator (prior to any examination required by research)
Exclusion
- Parkinsonian tremor
- Pregnancy or lactating women
- Severe co-morbidity (cardiac, renal or respiratory failures, evolutive cancer)
- Impaired cognitive functions (score \<130 on Mattis scale).
- Patients with severe atrophy or lesions on MRI
- Depression (Beck \> 10)
- Participation in another clinical research for 18 months (after surgery)
Key Trial Info
Start Date :
November 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 19 2020
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT02264925
Start Date
November 1 2014
End Date
November 19 2020
Last Update
August 13 2021
Active Locations (1)
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1
University Hospital Bordeaux, France
Bordeaux, France, 33076